nincs diacím.pptVIP

Heparinoids Danaparoid mixture of heparan sulfate (84%), dermatan sulfate (12%) and chondroitin sulfates inactivates mainly factor Xa (by accelerating antithrombin III) only parenteral use, s.c. - 100% bioavailability, half-life 25h used in case of HIT type II major toxicity is bleeding; can not be antagonized by protamine Direct thrombin inhibitors Hirudin derived from medicinal leeches (Hirudo medicinalis) recombinat analogue: desirudin binds directly to thrombin and irreversibly inactivates it parenteral use only (s.c. - 100% bioavailability) eliminated by the kidneys, half-l