基于小鼠大脑MRM图像灰度分布的个体结构网络构建 - 中国医疗设备.PDF

FEATURES 专 栏 基于小鼠大脑MRM图像灰度分布的个 体结构网络构建的研究 Study on the Construction of Individual Structure Network Based on Gray Level Distribution of Mouse Brain MRM Image 付振荣，林岚，张柏雯，吴水才 [摘 要] 结构磁共振成像脑网络分析技术结合了sMRI成像、医学图像处理、复杂网络及图论分析 北京工业大学 生命科学与生物工程学 等技术方法，通过对大脑不同感兴趣区之间的特征关系进行分析，能够更好地分析脑组织结构之 院，北京 100124 间的关系及与疾病的关联性等。目前，基于人脑sMRI的大脑灰质结构网络已成为脑网络研究的 一个热点，但是基于小鼠MRM 的大脑灰质网络分析还相对较少。本文首先通过构建基于KL散度 的小鼠MRM个体灰质脑网络，并在此基础上进行网络拓扑属性的分析，该方法可以应用于脑老 化和因疾病带来的小鼠脑网络变化的研究。 [关键词] 小鼠大脑；个体脑网络；KL散度 Abstract: The Structure Magnetic Resource Imaging (sMRI) network analysis, one of the most popular techniques for neuroimaging analysis, which integrates the techniques of the sMRI, imaging processing, complex networks and graph theory analysis et al, gives us a good understanding of the brain structural organization and its relationship with diseases. Nowadays, the network analysis for human brain based on ’ sMRI has attracted researchers attention, while the study for mouse brain magnetic resource microscopy is relatively rare. In this paper, the individual mouse structural networks were constructed based on Kullback-Leibler divergence of regional intensity distribution and a further analysis of network topology properties was made. This method can be used to study the age and disease related brain network changes in mouse brain. FU Zhen-rong, LIN Lan,