辐射接枝共聚合反应及其在有机生物医用材料制备中的应用Irradiation.PDF

2006 年第 26 卷 有 机 化 学 Vol. 26, 2006 第 9 期, 1328～1334 Chinese Journal of Organic Chemistry No. 9, 1328～1334 ·学术动态· 辐射接枝共聚合反应及其在有机生物医用材料制备中的应用 张 涛 a,b 侯小东 a,b 曹阿民*,b (a 上海交通大学化学化工学院 上海 200240) (b 中国科学院上海有机化学研究所 上海 200032) 摘要 γ-射线辐射高分子材料表面接枝共聚合是一种绿色的、重要的有机生物材料合成制备方法. 综述了 γ-射线辐射接 枝共聚反应的原理、特点, 阐述了预辐射接枝共聚和共辐射接枝共聚的方法, 介绍了当前 γ-射线辐射接枝共聚反应在改 善有机生物医用材料的表面亲水性、生物相容性等方面的应用. 对辐射接枝共聚合制备功能药物载体研究进行了简要 介绍. 关键词 γ-射线; 辐射接枝共聚; 预辐射; 共辐射; 有机生物医用材料 Irradiation Graft Copolymerization and Its Application for Preparation of Organic Biomedical Materials ZHANG, Taoa,b HOU, Xiao-Donga,b CAO, A-Min*,b a ( College of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240) (b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032) Abstract Irradiation graft copolymerization becomes a green and important synthetic strategy for surface functionalization and facile preparation of new organic biomedical materials. This article reviews the princi- ples and features of γ-ray irradiation graft copolymerization, and summarizes the biomedical applications of irradiation graft copolymerization to tailor surface from hydrophobicity to hydrophilicity, and their function- alization. Furthermore, as novel synthetic approach, the irradiation copolymerization was also employed to prepare new materials as functional drug carrier with controlled release. Keywords γ-ray; irradiation graft copolymerization; pre-irradiation; mutual radiation; organic biomedical materials