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Mikrochim. Acta 126, 193-202 (1997)
Mikrochimica Acta
9 Spfinger-Verlag 1997
Printed in Austria
Fundamental Review
Anti-Metatype Antibodies in Immunoassays
Edward W. Voss, Jr.* and Mark E. Mummert
Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Lab., 601 So. Goodwin, Urbana, IL 61801-3704,
U.S.A.
Abstract. In this review anti-metatype antibodies are FITC(I) fluorescein isothiocyanate (isomer I)
described invoking new principles in immunoassay Fv 26 kd fragment of the antibody molecule containing the
variable domains of the H and L chains
development. Anti-metatype antibodies are immuno-
Ig immunoglobulin
logical reagents specific for the conformation of the IgG immunoglobulin G with a mol. wt. of 150 kd.
liganded antibody active site which do not interact with IgM immunoglobulin M with a mol. wt. of 106d
idiotype
bound ligand or unliganded antibody. Relationships Id
Ka antibody affinity (kl/k2) in M-1
between anti-metatype antibody reactivit
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