心痛宁方对不稳定型心绞痛气虚血瘀证患者oxLDL的干预探究.pdfVIP

提 要 目的 本研究旨在观察心痛宁方对不稳定型心绞痛气虚血瘀证患者氧化低密度脂 蛋白（oxLDL）的干预研究，并初步探讨其作用机理。 方法 将60例不稳定型心绞痛气虚血瘀证患者随机分成试验组30例和对照组30 例，两组均予常规西药治疗，试验组加服心痛宁方。观察治疗前后两组患者相关症状 体征、心绞痛临床表现、心电图、血脂、血浆纤维蛋白原（Fg）、oxLDL 等指标的变 化情况。 结果 试验组临床症状明显改善，心绞痛总有效率为83.33%，对照组为46.67%， 两组差异比较有统计学意义(P＜0.05)。试验组心电图总有效率为70.00%，与对照组 的 60.00%比较差异有统计学意义(P＜0.05)。试验组能显著降低患者血清中血脂、 oxLDL的水平，与对照组比较，差异均有统计学意义（P＜0.05），疗效优于对照组。 结论 心痛宁方对气虚血瘀证不稳定型心绞痛有较好的治疗作用。其治疗机制可 能是通过调节血脂异常、抗氧化、保护内皮细胞功能等途径干预冠状动脉粥样硬化进 展。 关键词 不稳定型心绞痛；心痛宁方；临床研究 The Clinical Study on the effect of Xintongning Decoction in Treating the (Qi deficiency and Blood stasis) of Unstable Angina Pectoris(UAP) and oxLDL Speciality: Internal medicine of TCM Author: Li Yanfei Tutor: Pro. Zhang Yunhui ABSTRACT Objective To observe the clinical effect of Xintongning decoction treating unstable angina pectoris(Qi deficiency and blood stasis)patients and intervention function to vulnerable plaque ． Methods 60 patients were divided into two groups at random:the treatment group(30 cases)and the control group(30 cases).Two groups were treated with the western medicine convention strengthening treatment,but the treatment group was simultaneously treated with Xintongning decoction.After all around,we investigrated the effect of angina syndrom and electrocardiogram and changement of Blood fat,Fg，oxLDL. Results Chest rheumatism symptom of treatment group was improved distinctly.The effect of treatment group’s angina pectoris is 83.33%，the control group is 46.67% ，two groups have statistics difference(P ＜ 0.05).Total effect of treatment group’s electrocardiogram is 70.00%,it has statistics difference compared with the control group(P ＜0.05).Xintongning decoction canregulate the level of blood fat,oxLDL,the curative effect