肺纤维化（Pulmonary fibrosis）.docVIP

肺纤维化（Pulmonary fibrosis） Pulmonary fibrosis early alveolar inflammation, alveolar in serum and cell composition, pulmonary interstitial contains a large number of monocytes, part of lymphocytes, plasma cells, alveolar macrophage inflammatory cells infiltration and alveolar structure integrity. In the advanced stage, chronic inflammation has been reduced, the alveolar structure is a solid collagen replacement, the alveolar wall has been destroyed to form an expanding honeycomb lung. Collagen, extracellular matrix, fibroblast cells are distributed in the interstitial substance, and the alveolar epithelium is made up of squamous epithelium. Based on the above pathological changes, clinically characterized by progressive difficulty in breathing, or accompanied by stimulating dry cough, chest X-ray showed two lower lung field mesh shadow, lung function for restrictive ventilatory dysfunction. The disease progressed and eventually died of respiratory failure. Clinical manifestations of disease are hidden and progressive. The expression is progressive qi, dry cough phlegm or a small amount of white phlegm, the late emergence of hypoxemia mainly respiratory failure. It can be seen that the thoracic respiration is weakened, the lungs can smell and the fine wet or twirling sounds. There are different levels of purple and clubbing. Signs of right heart failure can occur in advanced stage. 1. Progressive qi, dry cough, wet lung or twirling of the lungs. 2. X-ray examination: the early stage was made of wool glass, typical change of diffuse line, nodular, cloud, reticular shadow and lung volume decreased. 3. Laboratory inspection: it can be seen that ESR and LDH increase, and generally have no special meaning. 4. Lung function examination: reduced lung capacity, reduced dispersion function and hypoxemia. 5. Lung biopsy provides the pathological basis. The disease should be noted for the identification of asthmatic branches. 1, glucocorticoid treatment (prednisone is also called