青蒿琥酯松弛气管平滑肌作用机制实验（Artesunate relaxant smooth muscle action mechanism experiment）.docVIP

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青蒿琥酯松弛气管平滑肌作用机制实验（Artesunate relaxant smooth muscle action mechanism experiment）.doc

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青蒿琥酯松弛气管平滑肌作用机制实验（Artesunate relaxant smooth muscle action mechanism experiment）

青蒿琥酯松弛气管平滑肌作用机制实验（Artesunate relaxant smooth muscle action mechanism experiment） Experiments on the mechanism of the smooth muscle of artesunate flabby trachea Update date: 2011-09-21 click: seedling Abstract: this paper deals with the mechanism of the relaxation of the smooth muscle of artesunate. The method of radiometric ligation and fura-2 / AM spectrophotometer were used. Results: artesunate was 10-7 ~ 10-4 mol/L, which had no significant effect on the combination of 0.8 nmol/L [3H] -qnb and SD rats salivary gland M3 - R (receptor) (n = 3, P BBB 0 0.05). 100.0 mu mol/L artesunate had no significant effect on intracellular calcium release and subsequent non-voltage dependence of intracellular calcium in guinea pigs induced by Cyclopiazonic acid (n = 3, P BBB 0 0.05). The results showed that the mechanism of the smooth muscle of artesunate flabby trachea may be independent of m-r and intracellular calcium release. Keywords artesunate; Toadin receptor; Cyclopiazonic acid; Radiometric ligand determination; Cytoplasmic calcium; Fluorescence spectrophotometer determination; Guinea pig tracheal smooth muscle cell Middle image classification no. : R285.5 document code: A post no. : 1008-0805 (2000) 03-0203-02 Study on the Action Mechanisms of Artesunates Tracheaectasy YANG Mao sheng - (Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, China) AbstractOBJECTIVE: To study the action mechanisms of artesunate s tracheaectasy. METHOD: Using radioligand assay and fluorescent spectrophotometer assay. RESULTS: artesunate of 10-7 ~ 10-4 mol/L had no effects on the binding between tendency for 0.8 / L [3 h] - QNB and M3 - receptor protein of salivary glands from SD rats (n = 3, P 0.05); 100.0 mu mol/L artesunate was not able to block both intracellular Ca2 + release and nonvoltage - depended Ca2 + influx induced by 10.0 u mol/L Cyclopiaxonic acid (n = 3, P 0.05) on cultured smooth muscle cells of guinea - pig tracheae. CONCLUSION: The action mechanisms of