穿刺活检术诊断前列腺癌及相关因素探讨.pdfVIP

Journal of Medical Forum Vo1．29 No．4 February 2008 · 21· 穿刺活检术诊断前列腺癌及 相关因素探讨 王晓甫，许长宝 郑州大学第二附属医院泌尿外科 郑州市 450014 摘要 目的 评价穿刺活检术在诊断前列腺癌中的临床意义并对影响因素进行探讨，提高前列腺癌的诊 断水平。方法 回顾分析156例疑诊前列腺癌(PCA)患者的临床资料，对前列腺癌的诊断方法进行探讨。结果 共发现前列腺癌97例，活检诊断93例，术后偶发癌4例。单项直肠指检(DRE)，经直肠超声(TRUS)诊断前列 腺癌阳性率与假阴性率分别为：73．1％、26．9％；77．4％、22．6％。所有前列腺穿刺活检标本均制作病理成功，诊 断阳性率95．9％，假阴性率8．9％。PCA阳性率与DRE及TRUS阳性率、PSA水平、患者年龄成正相关。结论 前列腺穿刺活检术诊断前列腺癌安全、可靠，与PSA、DRE、TRUS相结合可提高PCA诊断的敏感性与特异性。 关键词 前列腺癌；直肠指检；经直肠超声；前列腺穿刺活检 中图分类号：R737．25 文献标识码：B 文章编号：1672-3422(2008)04-0021-03 Detection of Clinical Significance and Influential Factors in Prostate Biopsy Diagnosing Prostate Cancer WANG Xiaofu，XU Changbao The Second Affiliated Hospital ofZhengzhou University，Zhengzhou 450014，China ABSTRACT 0bjective By evaluating the clinical significance of prostate biopsy in PCA diag— nosis and influential factors correlated，in order to elevate the diagnosis level of the prostate cancer． Methods The clinical data of 156 suspected prostate cancer(PCA)patients were retrospectively ana— lyzed．And then explore the diagnosis methods for prostate cancer．Student t—test and Pearson chi— square test were applied for statistical analysis subsequently．Statistical significance was defined as P 0．05．ReslIlts Total 97 PCA were diagnosed，of which 93 by prostate biopsy，4 by postoperative pathology．Single DRE．TRUS diagnosed 73．1％ and 77．4％ PCA patients successfully，but lost in 26．9％ and 22．6％ respectively．All of the biopsy specimens were transferred into pathologic essays successfully，and made the positive ratio of 95．9％ ，lost in 8．9％ respectively．We found that the posi— tive ratio of PCA was obviously correlated with DRE／TRUS positive rates，serum PSA leve