龙胆苦苷抗炎药理作用研究_陈长勋.pdfVIP

814 Chinese T r aditio nal and Her bal D rug s34 9 2003 9 1 2 3 1 1a 陈长勋 , 刘占文, 孙峥嵘, 宋纯清, 胡之壁 ( 1. , 200032; 2. , 200050; 3. , 200540) : , , A , ig , A , , : ; ; : R 286. 11: A : 0253 2670( 2003) 09 0814 03 Studies on anti-inflammatory effect of gentiopicroside 1 2 3 1 1 CHEN Chang -xun , L U Zhan-w en , SUN Zheng-rong , SONG Chun-qing , H U Z hi-bi ( 1. Shang hai U niv ersit y of T CM , Shang hai 200032, China; 2. Shang ha i T o ng r en Ho spit al, Shang hai 200050, China ; 3. Shang hai Jinshi M edicinal M ater ial Co. , L td, Shanghai 200540, China) Abstract: ObjectT o study t he ant i-inf lammat ory effect of gentiopicro side extracted f rom R ad ix Gen- tianae M arrop hy ll ae. MethodsT he m odels of aur icular edem a in m ice induced by dimethyl benzene, in- creased perm eability of celiac blo od capillary and body-tw ist ing react ion induced by acetic acid, paw sw elling induced by zym osan A , carrageenan and nyst at in in rat s or in m ice w ere prepared. T hen g ent iopi- . , cro side w as g iven t o t he r at s or m ice by ig Results Gent iopicro side inhibit ed t he auricular edem a de- creased the perm eability of celiac blood capillary, r educed t he paw sw elling induced by carr ageenan and zy- , . mosan A but not by ny st at io n Conclusion Gent iopicro side ex tract ed f rom R ad ix Gentianae M arrop hy l- , - . lae ex hibits o bvious ant i inflamm ato ry effects : ; ; - Key words R ad ix Genti anae M arr op hy l lae gen