温阳活血法对冠状动脉痉挛患者hU-Ⅱ、TM的干预探究.pdfVIP

提 要 目的：观察温阳活血法治疗冠状动脉痉挛阳虚血瘀证的临床疗效，并通过对hU- Ⅱ和TM的干预作用，探究温阳活血法对冠状动脉痉挛的干预机制。方法：选择冠状动 脉痉挛阳虚血瘀证患者60例，随机分为对照组（30例）和试验组（30例）。分别予以 贝尼地平和心痛宁方合贝尼地平治疗，4周后观察两组患者心绞痛发作情况、中医证 候变化、血脂及hU-Ⅱ、TM的变化。结果：治疗后试验组在心绞痛疗效、中医证候疗 效方面优于对照组，均有显著性差异（P＜0.05）；试验组能明显降低心绞痛发作次数 和持续时间，较对照组有显著性差异（P＜0.05）；治疗后试验组TC、TG、LDL-C、hU- Ⅱ、TM均下降，较对照组有显著性差异（P＜0.05）。结论：温阳活血法是治疗冠状动 脉痉挛阳虚血瘀证的有效方法，心痛宁方能显著改善冠状动脉痉挛患者的心绞痛症状 2+ 和其他临床表现，调节血脂代谢，抑制Ca 内流，改善血管内皮功能，从而减轻冠状 动脉痉挛发作。 关键词 温阳活血法；冠状动脉痉挛；阳虚血瘀证；hU-Ⅱ；TM The Intervention Research of hU- Ⅱ、TM on Coronary Artery Spasm Patients with WenYangHuoXue Method Speciality: Clinical study on the treatment of heart system disease with Traditional Chinese Medicine Tutor:Prof.Zhang Yunhui Author:Ma Zhaolin Abstract Objective:To observe the clinical effect of WenYangHuoXue Method on the Coronary Artery Spasm (CAS) patients with Yang-deficiency and blood stasis syndrome,and probe its mechanism of action by the intervention effect of hU- Ⅱand TM. Methods:60 CAS patients with Yang-deficiency and blood stasis syndrome was divided into control group (n=30) and experiment group (n=30) randomly.The control group was treated with Diltiazem,while the experiment group was treated with XinTongNing Decoction and Diltiazem.Four weeks later,we observe the condition of anginal attack and the changes of Traditional Chinese syndrome,blood-fat, hU- Ⅱand TM of two group patients. Result:After treatment,curative effect in experiment group patients is significantly better than that in control group patients on anginal,Traditional Chinese syndrome, TC,TG,LDL-C,hU- Ⅱand TM(P＜0.05);And also XinTongNing Decoction can obviously decreased the an