温阳潜镇安神汤治疗阳虚型失眠的疗效观察及机理探讨.pdfVIP

提 要 目的：探讨温阳潜镇安神汤治疗阳虚型失眠的疗效观察和机理。方法：将符合纳 入标准的失眠患者60例，随机分为温阳潜镇安神汤组（实验组）30例，甜梦胶囊组 （对照组）30 例，分别运用相应药物对其进行临床治疗，疗程均为 3 周。观察治疗 前后患者 PSQI 量表、中医症状评分的变化。结果：1.按照《中药新药临床研究指导 原则》标准评价的临床疗效比较，实验组总有效率为 96.67%，对照组总有效率为 76.67%，两组临床疗效之间有显著性差异（P＜0.01）。2. 按照PSQI改善率评价疗效 比较，实验组愈显率73.34%，总有效率100%；对照组愈显率6.66%，总有效率46.67% ； 两组疗效比较差异有统计学意义（P ＜0.05）。3. 在 PSQI 总分及各成分比较方面， 两组总体疗效有显著差异，实验组优于对照组（P＜0.05）。4.在中医临床症状总分比 较方面，实验组在改善中医症状总分方面优于对照组(P ＜0.01)。结论：温阳潜镇安 神汤能有效改善患者失眠症状，对精神不振、腰膝酸软、形寒肢冷、心烦、惊悸、健 忘等伴随症状也有明显疗效。证实温补心肾，潜镇安神法治疗失眠症具有较好的临床 适用性。 关键词 失眠；温阳潜镇安神汤；临床研究 WenYangQian town anshen decoction in the treatment of insomnia curative effect observation of Yang and mechanism is discussed Speciality: Neurological medicine of TCM Author: RenDengFeng Tutor: Prof.Wang Zhonglin Abstract Objective: to explore the WenYangQian nerves decoction in the treatment of insomnia clinical observation of rats and mechanism. Methods: met inclusion criteria of 60 cases, insomnia patients were randomly divided into WenYangQian town anshen soup group (group) 30 cases, sweet dream capsule group (control group), 30 cases were using drugs on the corresponding treatment for clinical treatment are 3 weeks. Observed before and after treatment PSQI scale, Chinese medicine with changes of the symptom score. Results: 1. According to Chinese herbal medicine clinical research guiding principle of the clinical curative effect of standard evaluation comparison, the total effective rate of the treatment group and control group total effectiveness is 96.67% 76.67%, between two groups of clinical curative effect was significant difference (P 0.01). 2. Compare PSQI period in accordance with, and the therapeutic evaluation and greater 73.34%, with the total effective rate of 100%; The control