滋水清肝熄风汤干预颈动脉粥样斑块的临床探究.pdfVIP

提 要 目的：观察滋水清肝熄风汤干预颈动脉粥样斑块的临床疗效，并探讨其作用机制。 方法：采用随机分组的方法，将符合纳入标准的60例颈动脉粥样斑块形成患者分为 治疗组和对照组两组，每组各30人。治疗组采用滋水清肝熄风汤加每日5mg瑞舒伐 他汀治疗；对照组采用每日5mg瑞舒伐他汀治疗，6个月为一个疗程。治疗前后观察 患者内膜中层厚度（IMT）、粥样斑块积分、血脂、血压、高敏CRP等指标及患者症候 变化情况。结果：治疗组的症状改善总有效率为（90.0%），显效率为（60.0%），与 对照组相比较有显著性差异(P0.01)；治疗组内膜中层厚度（IMT）明显减轻，与对 照组比较有差异(P0.05)，粥样斑块积分明显减少，与对照组比较有显著性差异(P 0.01)；治疗组TC、LDL-C、TG明显降低，HDL-C明显升高，与对照组比较TC、LDL-C、 TG有差异(P0.05或0.01)，HDL-C无显著差异(P0.05）；治疗组收缩压及舒张压明 显降低，与对照组比较有差异(P0.05)；治疗组高敏CRP明显降低，与对照组比较有 差异(P0.05)。结论：滋水清肝熄风法是治疗颈动脉粥样斑块的一种有效方法，并具 有调节血脂、降低血压及抗炎的功能。 关键词 颈动脉粥样斑块；肾虚肝旺证；滋水清肝熄风汤；临床研究 The Clinical Study on Carotid Artery Atherosclerotic Plaque by Zishuiqingganxifeng Decoction Speciality：Internal Medicine of Traditional Chinese Medicine Author ：Xue qian Tutor ：Prof.Bao Pei-rong Abstract Objective: To oberseve the clinical effect of the Zishuiqingganxifeng Decoction to Carotid Artery Atherosclerotic Plaque and explore its mechanism of effect. Methods: 60 cases of carotid atherosclerosis with the type of defieiency of kidney and hyperactivity of liver-fire were randomly divided into treatment group(30 cases)and control group(30 cases).The treatment group was dosed at Zishuiqingganxifeng Decoction and 5mg Rosuvastatin Tablets.And the control group was dosed at 5mg Rosuvastatin Tablets.The treatment cycle is six months.The changes of laboratory indexes that including IMT,plaque score,TC,TG,LDL-C,HDL-C,blood pressure，Hs-CRP and clinical symptom were observed before and after treatment in both groups. Results: In the treatment group,the total effective rate of meliorating symptoms and the remarkab