滋阴清热法治疗慢性肾小球肾炎的临床探究.pdfVIP

提 要 目的：观察滋阴清热法（竹叶石膏汤合二至地黄汤加减）为主，治疗慢性肾小 球肾炎的临床疗效，并从现代医学角度深入探讨其作用机理。方法：将符合入选标 准的 72 例慢性肾小球肾炎患者随机分为两组，治疗组与对照组均给予血管紧张素 Ⅱ受体阻滞剂（ARB ）控制血压，其中治疗组 36 例予以竹叶石膏汤合二至地黄汤 加减治疗；对照组 36 例，予以肾炎康复片治疗，用药 2 个月为一个疗程，两组均 服用 1 个疗程。结果：治疗组患者的临床证候总积分明显降低，疗效明显优于对照 组(P＜0.01)；治疗组患者的 24h 尿蛋白定量水平明显降低，疗效明显优于对照组 (P＜0.05)；治疗组患者的超敏 C 反应蛋白、尿蛋白、尿潜血、尿素氮、血肌酐水 平明显降低，疗效优于对照组（P＜0.05）；血脂、血压、补体C3两组相比无明显 差异，无统计学意义（P＞0.05）。结论：以竹叶石膏汤合二至地黄汤加减为代表 的滋阴清热法治疗慢性肾小球肾炎疗效明显优于肾炎康复片。 关键词 慢性肾小球肾炎；中医药疗法；滋阴清热法；竹叶石膏汤合二至地黄汤； 临床研究 Clinical Research on Treatment of Chronic Glomerulonephritis with Nourishing Yin and Clearing Heat Speciality：Internal medicine of Traditional Chinese Medicine Author：Qu Zongxu Tutor：Prof.Yu Junsheng Abstract Objective：In order to observe the clinical effect of the treatment with nourishing Yin and clearing heat for chronic glomerulonephritis，and the treatment is implemented mainly through Modified Zhuyeshigao and Erzhidihuang soup, explore its mechanism according to the perspective of modern medicine. Methods：72 patients diagnosed the chronic glomerulonephritis were randomly classified into two groups．Both the two groups were treated with Angiotensin Ⅱ receptor blockers to control the blood pressure. 36 patients were treated with Modified Zhuyeshigao and Erzhidihuang soup in treated group; others were treated with Shenyankangfu tablet in control group. Two months were a course of treatment. Both groups were taking a course of treatment. Result：The patients’ clinical symptoms total score of treatment group was significantly reduced, significantly better than the control group (P0.01). The 24h urinary protein of treatment group were significantly lowered, significantly better than the control group (P0.05). The patients’ hypersensitive C-reactive protein , urine protein, urine occult blood, blood urea nitrogen, serum creatinine of treatment group were signi