输卵管节育器阻断病原体上行感染的病理组织学基础探究.pdfVIP

提 要 目的：通过观察新西兰大白兔于输卵管间质部放置可逆性输卵管节育器，注入细 菌后子宫、输卵管、卵巢粘膜的组织病理学的变化，探讨该节育器对病原体经生殖道 粘膜上行感染的阻断作用的病理学依据。 方法：将6-8月龄体重3±0.5kg雌性新西兰大白兔30只随机分为三组，手术组行 输卵管间质部可逆性输卵管节育器放置术，假手术组重复手术过程，但不放置节育器， 空白对照组不做任何处理。三组实验动物均在同一环境下常规饲养。术后恢复性饲养 一个月，手术组及假手术组动物均采用经阴道注入混合菌液方法建立慢性盆腔炎动物 模型，空白对照组不予处理。术后28天手术剥离新西兰兔子宫、输卵管、卵巢部分粘 膜组织进行病理组织学检查。 结果：病理组织切片可见：手术组新西兰兔子宫内膜、卵巢间质少量慢性炎细胞 浸润，输卵管上皮轻度增生，其余基本正常；假手术组新西兰兔子宫内膜、卵巢、输 卵管间质慢性炎细胞浸润；空白对照组新西兰兔子宫内膜上皮、子宫内膜腺体基本正 常；输卵管、卵巢基本正常。 结论：从病理切片结果分析，新西兰兔输卵管间质部放置可逆性输卵管节育器可 有效阻止病原微生物经输卵管粘膜继续上行引发盆腔感染，从而达到预防盆腔炎发生 的目的。 关键词 输卵管节育器；盆腔炎；上行感染；病理组织学 The tubal IUD block infection by pathogens upstream histoputhological basic research Speciality:Gynecology of TCM Author:Fan huanong Tutor: Professor Wang Zhe Abstract Objective：By observing the New Zealand rabbits were placed reversible tubal IUD interstitial tubal mucous membrane of the uterus, fallopian tubes, ovaries histological and pathological changes in the injected bacteria, investigate the blocking effect of the IUD ascending infection of the pathogen through the genital tract mucosa pathological basis. Method ：6-8 month weight ± 0.5kg, 30 female New Zealand white rabbits were randomly divided into three groups, interstitial tubal surgery group underwent reversible tubal IUD placed surgery, the sham operation group, repeat surgical procedures, but not placed on birth control. The control group received no treatment .Three groups of experimental animals in the same environment under conventional breeding. Postoperative recovery was feeding a month, the surgery group and the sham group by vaginal injection of mixed bacteria to establish the animal model of chronic pelvic inflammatory disease, and t