神经内镜手术治疗老年女性颅底肿瘤的可行性及安全性研究.doc.docVIP

神经内镜手术治疗老年女性颅底肿瘤的可行性及安全性研究 Feasibility and safety of endoscopic surgery in the treatment of skull base tumors in elderly women 摘要 目的 对神经内镜手术治疗老年女性颅底肿瘤的疗效及安全性进行研究，证实神经内镜手术的临床价值，为其推广提供数据支持。 方法 选取2013年9月-2014年9月间治疗的老年女性颅底肿瘤患者82例为研究对象，将其随机分为观察和对照组，分别予以神经内镜手术治疗和常规手术治疗，并对其手术成功率、疗效及安全性进行组间比较及统计学分析。 结果 对两组研究对象的年龄、病程、病理检查结果等基线资料进行组间比较均无显著差异性（P＞0.05）；观察组术成功率为95.2%，对照组手术成功率为97.5%，组间比较，无显著差异性（P＞0.05）；两组研究对象总受益率分别为90.5%和92.5%，对照组虽略有优势，但无显著差异性（P＞0.05）；并发症发生率分为14.3%和32.5%，观察组具有显著优势（P＜0.05）。 结论 神经内镜手术是治疗老年女性颅底肿瘤安全可行的方法，具有推广价值。 关键词：神经内镜手术；常规手术；老年女性；颅底肿瘤；可行性；安全性 Abstract Objective to study the efficacy and safety of endoscopic surgery in the treatment of skull base tumors in elderly women, and to confirm the clinical value of endoscopic surgery, and to provide data support for the clinical application. Methods from September 2013 - 2014 September therapy in elderly female patients of skull base tumors 82 cases as the research object, divided for observation and control group, were treated with endoscopic surgery and conventional surgical treatment, and on the efficacy and safety of group comparison and statistical analysis. Results of two groups of subjects age, course of disease, pathological examination results of baseline data were between the two groups showed no significant difference (P0.05). The patients in the observation group success rate was 95.2%, control group operation success rate was 97.5%, between the groups, there was no significant difference (P 0.05); two groups of subjects total benefit rate was 90.5% and 92.5%, control group, although a slight advantage, but no significant difference (P0.05). The complication rate was 14.3% and 32.5%, the observation group has a significant advantage (P0.05). Conclusion endoscopic surgery is a safe and feasible method for the treatment of skull base tumors in elderly women. Key words: endoscopic surgery; conventional surgery; elderly women; skull base neoplasms; feasibility; safety 颅底肿瘤虽然发病率不高，但其发病部位特殊，大部分