四环素类抗生素降解途径及其主要降解产物研究进展 - 应用生态学报.pdfVIP

应 用 生 态 学 报摇 2012年8月摇 第23卷摇 第8期摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 ChineseJournal of Applied Ecology,Aug. 2012,23(8):2300-2308 四四环素类抗生素降解途径及其主要 降解产物研究进展* ** 李伟明摇 鲍艳宇 摇 周启星 (南开大学环境科学与工程学院教育部环境污染过程与基准重点实验室/ 天津市城市生态环境修复与污染防治重点实验室, 天津300071) 摘摇 要摇 四环素类抗生素在生产和贮存过程中会发生一系列非生物降解反应,其中某些代谢 及降解产物,与母体相比,虽然其活性降低,但毒性却大大增强.此类抗生素随着畜禽废弃物 等途径进入到环境中,随环境条件的不同将发生一种或多种降解反应,其降解方式除了非生 物降解外,还包括生物降解.本文综述了四环素类抗生素在不同生态环境中的降解途径以及 降解产物,并对今后的研究方向进行了探计,旨在为其生态风险评价提供有价值的参考. 关键词摇 四环素类抗生素摇 降解途径摇 降解产物摇 生态毒性 文章编号摇 1001-9332(2012)08-2300-09摇 中图分类号摇 X53,X171.5摇 文献标识码摇 A Degradation pathways and main degradation products of tetracycline antibiotics:Research progress. LI Wei鄄ming,BAO Yan鄄yu,ZHOU Qi鄄xing (Ministry of Education Key Laboratory of Pollution Process and Environmental Criteria/ Remediation and Pollution Controlfor Urban Ecologi鄄 cal Environment, College of Environmental Science Engineering, Nankai University, Tianjin 300071,China).鄄Chin.J.Appl.Ecol. ,2012,23(8):2300-2308. Abstract:Tetracycline antibiotics (TCs) can produce a series of abiotic degradation reactions in the processofproductionandstorage,andsomeofthedegradationproductshavelowerantibacterial activity but higher toxicity,as compared to the parent antibiotics. TCs can enter the environment via the disposal of livestock andpoultry wastes,andthen degrade in one or morewaysaccordingto the external conditions. Besides abiotic degradation,bio鄄degradation also happens. This paper re鄄 viewed the degradation pathways and main degradation products of TCs in different ecological envi鄄 ronments,and discussed thefuture research directions,aimed to provide valuable referencefor the ecological risk assessment of the antibi