慢性血液透析患者透析前后血浆同型半胱氨酸的变化 - 中南大学学报 .pdfVIP

266 BULL HU A MED U IV 2003, 28( 3) 1 1 1 2 1 1 2 王海涛 ,彭佑铭 ,刘 虹 , 戴崇文 , 段绍斌 , 刘伏友 , 张广森 ( 中南大学湘雅二医院1.肾脏病研究所; 2.分子血液病研究室, 长沙410011) [] 目的:通过对慢性血液透析患 透析前后血浆同型半胱氨酸的检测, 了解血液透析(聚砜膜F7透析 器) 对慢性血液透析病人血浆同型半胱氨酸水平的影响方法: 11例慢性血液透析患 , 分别于透析前后 10 min 采取血样,另选30 例正常志愿 为对照组,抽取清晨空腹静脉血,肝素抗凝, 于30 min 内低温离心7 min( 700 g) , 分离血浆,采用高效液相色谱仪检测血浆同型半胱氨酸水平结果: 慢性血液透析患 血浆同型半胱氨酸水 平透前为( 29.53 13. 59)mol/L 及透后为( 21.30 10.81) mol/L, 均明显高于正常对照组( 13. 54 4.49) mol/L ( P 0.01) ; ! 慢性血液透析患 同型半胱氨酸水平透析后较透析前明显降低( P 0.01) 结论: 慢性肾功能 不全血液透析患 的血浆同型半胱氨酸平均水平高于正常人; ! 血液透析( 聚砜膜F7 透析器) 可以降低慢性肾 功能不全血液透析患 血浆同型半胱氨酸的水平, 对同型半胱氨酸有清除作用,但不能使同型半胱氨酸水平降至 正常 [] 血液透析; 肾功能衰竭, 慢性; 高同型半胱氨酸血症; 色谱法, 高压液相 [] R692.5; R458. 5 [] A [] 2003 Alteration of homocysteine before and after hemodialysis in chronic hemodialysis patients WA GHaitao, PE G Youming, LIU Hong, et al . ( I nstitute of Nep hrology , Second X iangya H ospital , Central S outh University , Changsha 410011, China ) Abstract: Obj ective To determine the plasma hemocysteine (Hcy) concentration in chronic hemodialysis patients and controls, and the relation between chronic hemodialysis and the plasma total Hcy level in chronic hemodialysis patients. Methods Using HPLCFLD method, the plasma total Hcy concen tration was determined in 11 patients with chronic hemodialysis and 30 healthy volunteers. Results The plasma total Hcy level in chronic hemodialysiswas significantly higher than that in