齿叶白鹃梅叶子对小鼠糖耐量的影响以及降糖作用的研究.docVIP

齿叶白鹃梅叶子对小鼠糖耐量的影响以及降糖作用的研究 王聪， 刘玉强， 才谦* （辽宁中医药大学，辽宁 大连 116600） 摘要： 目的： 探讨齿叶白鹃梅叶子对正常和糖尿病小鼠糖耐量的影响以及对STZ诱导糖尿病小鼠的降糖作用。方法： 采用腹腔注射链脲佐菌素(150mg/kg ) 诱导小鼠造成糖尿病模型， 先观察齿叶白鹃梅叶子水提物和80%醇提物对正常和糖尿病小鼠糖耐量的改变；再观察齿叶白鹃梅叶子的水提取物和80%醇提物物以及阳性药盐酸二甲双胍（333mg/kg）对小鼠血糖值的影响。结果：糖耐量实验表明齿叶白鹃梅叶子水提物和80%醇提物能降低正常和糖尿病小鼠餐后 1 h和2 h血糖，并且齿叶白鹃梅水提物对糖尿病小鼠餐后2 h血糖具有显著降低作用（P0.05）；降血糖药理实验表明齿叶白鹃梅叶子的水提物大剂量与醇提取物大剂量均能降低STZ致糖尿病小鼠的血糖，且齿叶白鹃梅叶子水提物大剂量组的降糖作用优于齿叶白鹃梅叶子醇提物大剂量组的降糖作用。结论：齿叶白鹃梅叶子能改善正常和链脲佐菌素糖尿病小鼠糖耐量，并具有一定的降糖作用。 关键词：齿叶白鹃梅； 糖尿病； 血糖； 链脲佐菌素； 小鼠 Effects of leaves of Exochorda serratifolia S.Moore on the glucose tolerance in mice and Hypoglycemic effect on STZ induced diabetic mice Wang Chong， Liu Yu-qiang， Cai Qian* （Liaoning University of TCM，Dalian Liaoning，1l6600） leaves of Exochorda serratifolia S.Moore on the glucose tolerance in normal and diabetic mice and to study the hypoglycemic effect on STZ induced diabetic mice．Methods：First，diabetic mice model was induced by STZ(150mg/kg). Normal or diabetic mice were given a single dose of the water extract from leaves and the 80% EtOH extract from leaves，and the changes of glucose tolerance were observed respectively；Second，The water extract and the 80% EtOH extract was administrated at different does (9.5g/kg,3.8g/kg) to the STZ induced mice for 10 days．The mice of positive control group were given meformin hydrochloride (333mg/kg)．And then ,the levels of blood glucose were inspected． Results：The water extract and the 80% EtOH extract could lower the serum glucose levels 1h and 2h after glucose administration in normal or diabetic mice. And the water extract could lower the the serum glucose levels 2h after given glucose in diabetic mice(P0.05)；The blood glucose level was lower remarkably in the hyperglycemia mice that were administrated at high dose of the water extract of leaves of Exochorda serratifolia S.Moore (P0.05)．Conclusion：The leaves of Exochorda serratifolia S.Moore could improve the glucose tolerance in normal and diabetic mice induced by STZ and also ha