原创力文档Biochemical changes during exchange transfusion in hyperbilirubinemia in term newborn babies：（生化变化在交换输血在项新生儿高胆红素血）.pdfVIP
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BIOCHEMICAL CHANGES DURING EXCHANGE TRANSFUSION IN HYPERBILIRUBINEMIA IN TERM
NEWBORN BABIES
AMIT JAIN, D. PURl*, and M.M.A. FARIDI
Departments of Pediatrics and Biochemistry*, University College of Med. Sciences Guru Teg Bahadur
Hospital, Delhi 110 095
ABSTRACT
Double volume (170 ml/kg body weight) exchange transfusion was done in 52 term infants
in the first week of life for neonatal hyperbilirubinemia. The M:F ratio was 1.08:1 and 37
(71.1%) babies were of low birth weight. Causes of jaundice were hemolytic in 46.2% and
non-hemolytic in 41.3% cases; in 13.5% babies no cause of jaundice could be found. After
exchange transfusion a fall of 14.6% and 47.4% was observed in the hemoglobin and serum
bilirubin levels respectively. There was significant (p=0.0414) rise in the mean mid exchange
and post-exchange serum sodium levels as compared to pre-exchange values and it was
found to be due to higher donors serum sodium levels (p=0.007). There was no effect on
the serum potassium levels during or after ET.
In general serum calcium levels significantly increased at mid-exchange period (p=0.0029)
but post-exchange levels were same as pre-exchange. Donors serum calcium level had
no effect on the infants serum calcium level (p=0.993). There was no change in the serum
phosphate and blood urea levels during and after exchange-transfusion. The plasma
glucose was significantly raised during and after ET and plasma glucose of the donors
had s
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