Biochemical composition of benign thyroid cyst fluid：（生化成分的良性甲状腺囊肿液）.pdfVIP

OCopyright 1997by Humana Press Inc. All rights of any nature whatsoever reserved. 0163-4984/97/5701-0009 $10.25 Biochemical Composition of Benign Thyroid Cyst Fluid METIN OZATA, •1 ISMAIL KURT, 2 MUHITTIN A. SERDAR, 2 M . EMIN O N D E , 1 AHMET AYDIN, 3 AHMET CORAKCI, 1 AND M . A U GUNDOGAN 1 Departments of Endocrinology and Metabolism, 2Biochemistry, and 3Pharmaceutical Sciences, Gulhane School of Medicine, Etlik-Ankara 06018 Turkey Received February 20, 1996; Accepted April 4, 1996 ABSTRACT Although the availability of thyroid cyst fluid is easy by fine- needle aspiration, less is known about the biochemical composition of thyroid cyst fluid. The authors have, therefore, determined the bio- chemical composition of 18 benign thyroid cyst fluid specimens. They found that the activities of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and the concentrations of total protein, total bilirubin, and uric acid were highly increased in thyroid cyst fluid speci- mens when compared with normal human serum specimens. The con- centrations of glucose, cholesterol, and triglycerides in cyst fluid were within normal serum limits. Selenium (Se) concentrations in most cyst fluids were low. Moreover, there was no correlation between Se and other biochemical parameters. Protein electrophoresis of cyst fluid speci- mens yielded high concentrations of ~1 and especially o~2 globulin frac- tions indicating an inflammation.