Biocompatible α-aminoacids based aliphatic polyamides：（基于生物相容性α-aminoacids脂肪族聚酰胺）.pdfVIP

Polymer Bulletin 39,279-286 (1997) Polymer Bulletin © Springer-Verlag 1997 Biocompatible aaminoacids based aliphatic polyamides B. Bianco, L. Castaldo, A. del Gaudio, G. Maglio l , R. Palumbo * , F. La Cara t , G. Peluso2 , 0. Petillo2 Dipartimento di Chimica, University Federico II , Via Mezzocannone 4, I -80134 Napoli, Italy 2 Istituto di Biochimica delle Proteine ed Enzimologia, C.N.R., Via Toiano 6, I -80072 Arco Felice, Napoli, Italy Received: 28 May 1997/Revised version: 16 July 1997/Accepted: 16 July 1997 Summary Biodegradable aliphatic polyamides have been prepared from Cl 0 and Cl 4 dicarboxylic acids and amide-diamines containing one or two preformed amide linkages susceptible to enzymatic cleavage in their molecules. L-phenylalanine, either by itself or together with L- valine, was used to generate amide bonds which are cleavable by chimotrypsine. Improved chain flexibility and hydrophilicity of the polyamides was obtained using a triethyleneoxy based amide-diamine. Characterization of the novel monomers and polymers by FTIR and H-NMR spectroscopy confirms the expected structures. Thermal data and solubility tests indicate that both Tm and solubility depend on the length and nature of the aliphatic segment present in the amide-diamine as well as on the density of interchain hydrogen bonds. Finally the polymers tested are capable of supporting fibroblast adherence and proliferation, and proved to be non cytotoxic. Introduction Aliphatic polyamides (PAs) are interesting materials for application in medicine due to their physico-mechanical properties and biocompatibility. In recent years, efforts have been directed towards the preparation of biodegradable, resorbable condensation copolymers containing amide bonds (polyesteramides and polyurethaneamides)