奥美拉唑对脑出血应激性溃疡的预防效果.pdfVIP

·614· 奥美拉唑对脑出血应激性溃疡的预防效果 丁凤英 罗伟良 【摘要】 目的观察奥美拉唑治疗高血压性脑出血并发应激性溃疡出血的疗效。方法 将100例高血 压性脑出血患者分为奥美拉唑组(50例)和对照组(50例)，均予常规脱水、降颅压及对症支持治疗，奥美拉唑 组加用奥美拉唑40mg，静脉注射，1次／d，共14d。结果奥美拉唑组应激性溃疡6例(12．0％)，明显低于对 照组12例(24．0％)；两组应激性溃疡发生率均随病情程度加重而增加；奥美拉唑组死亡3例(6．O％)，明显低 于对照组8例(16．0％)(P(0．05)。结论奥美拉唑静脉注射预防高血压性脑出血并发应激性溃疡出血疗 效确切，且未见不良反应发生。 【关键词】颅内出血，高血压性；奥美拉唑；消化性溃疡；应激 Evaluatetheeffectto in treatmentof cerebral withstressulcer omeprazolepreventing hypertensivehemorrhage DING Center 75 bleeding ofPharmacy，HuizhouPeopleHospital， Feng-ying’，LUO耽一liang．’Department 516001，China H讲zhOU，Cruangdong Toevaluatetheeffectof in treatmentof cerebral 【Abstract】0bjective omeprazolepreventing hypertensive withstressulcer Atotalof100 with cerebral hemorrhage bleeding．Methods patientshypertensivehemorrhage weretreatedwithconventional and treatment．The therapyincludingdehydration，antihypertensivesupporting pa- tientswere dividedinto 50)andcontrol control received randomly omeprazolegroup(以5 group(以=50)．Thegroup conventionaI the receivedadditional 14d．Results therapyonly，whileomeprazolegroup omeprazole40mg，iv，qd，for stressulcer6 lowerthanthecontrol 12 caess(12．0％)was cases(24．0％)； Omeprazolegroup significantly group tWO stressulcerincidence are withtheincreaseofthe mortalitiesofcerbral groups of increasing disease；the severity were6．0％inthe 16．0％inthecontrol andthedifferencehad hemorrhage and significant omeprazolegroup group has beneficialeffectin meaning(P0．05)．Conclusio