妇舒保凝胶精制、浓缩 及干燥工艺研究.PDFVIP

·622 · 国际中医中药杂志2017年7月第39卷第7期 Int J Trad Chin Med, July 2017, Vol. 39, No.7 ·实验与方药 · 妇舒保凝胶精制、浓缩 及干燥工艺研究 张月婵 王建春 杨锐 【摘要】 目的 优选中药复方制剂妇舒保凝胶的精制、浓缩及干燥工艺。方法 本试验以大黄酸、 大黄素、大黄素甲醚总含量的保留率和纯度为评价指标，优选水提液精制工艺，以大黄酸、大黄素、大 黄素甲醚总含量和盐酸小檗碱含量的转移率及干燥品外观性状为评价指标，比较常用的浓缩、干燥方法， 优选出最佳浓缩、干燥工艺。结果 最佳精制工艺为 0.2 g/ml 水提液在 70 ℃下加入ZTC1 ＋1- Ⅱ型澄清 剂 B 组分 0.6 ml/g，搅拌 10 min，70 ℃水浴保温 30 min ；再加入A 组分 0.3 ml/g，搅拌 10 min，70 ℃水 浴保温 30 min ；静置 12 h，过滤。最佳浓缩、干燥工艺为在真空度为-0.08～-0.09 MPa，温度为 60 ℃的 条件下减压浓缩至相对密度约为 1.05 后，将浓缩液喷雾干燥。结论 优选出的妇舒保凝胶精制、浓缩、 干燥工艺稳定可行、科学合理，可为大生产提供依据。 【关键词】 中药制药工艺；妇舒保凝胶；精制工艺；浓缩工艺；干燥法 Study on purification, concentration and drying technic of Fushubao gel * Zhang Yuechan , * Wang Jianchun, Yang Rui. Department of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Suzhou 215600, China Corresponding author: Wang Jianchun, Email: 【Abstract 】 Objective To study the purification, concentration and drying technology of Fushubao gel. Methods The purification technology of Fushubao gel was optimizing by the total retention rate of Rhein, emodin, physcion and purity of content. The concentration, drying technology of Fushubao gel was optimized by the transfering rate of Rhein, emodin, physcion and Berberine hydrochloride. Results Best refining technology included in the condition of the water extract of 0.2 g/ml at 70 ℃, the ZTC1＋1-II clarifying agent B 0.6 ml/g was mixed10 min in a 70 ℃ water bath thermal insulation 30 min; And then agent A 0.3 ml/g was added and mixed 10 min in a