甲胺对兔心血管内皮的慢性毒性.pdfVIP

中国药理学与毒理学杂志 2008年2月； 22(1)：24—30 · 24· Chin J PharmacoZ ToxicoZ 2008 Feb； 22(1)：24—30 Chronic toxicity of methylamine on cardiovascular endothelium of rabbits LUO Wen-Ying，LIN Zhe-Xuan，LI Hui，LUO Wen-Hong (Central Laboratory，Medical College，Shantou University，Shantou 515031，China) Abstract：A T0 study whether chronic adminis． It has been reported that increased serum SSAO tration of methylamine may induce elevation of semicar． activities were found in patients with diabetic bazide．sensitive amine oxidase(SSAO)activity and complications，vascular disorders and heart dis— initiate the iniury of cardiovascular endothelium． ease -3j M THoDS New Zealand rabbits were treated with ． Methylamine(MA)is both an exog— methylamine hydrochloride(100 mg·kg )by ig， enous(present in cigarette，wine and foods) once a day for 6 months．The rabbits were weighed ev． and endogenous amine．and it is a metabolic ery other week and the dosage was adjusted according product of diverse compounds，including epi— to the body weight．The number of circulating endothe． nephrine， carbamate insecticides， creatine， 1ial cells(CEC)in the a~erial blood．nitric oxide nicotine．and sarcosine【 。 ．It is preferentially (NO)concentration in the serum and uhrastructure of endothelial cells of a0rta were assessed．The plasma metabolized by SSAO rather than other amine SSA0 activity and formaldehyde concentration were as． oxidases J．Although MA itself is relatively sessed by liquid chromatography．RESULTS The