甲状腺嗜酸细胞性肿瘤临床病理分析.pdfVIP

· 临床研究· 2008年1月第46卷第1期 甲状腺嗜酸细胞性肿瘤临床病理分析 王贤兴 蒲彦武 王 东 周 波 翟丽芳 (解放军第二五医院病理科，甘肃酒泉735000) 【摘要】目的 提高对甲状腺嗜酸细胞肿瘤的临床病理特点、诊断与鉴别诊断的认识，减少误诊。方法 对2例甲状腺嗜酸细 胞性肿瘤进行临床病理分析及免疫组织化学染色观察，并复习相关文献。结果 1例嗜酸细胞性腺瘤，1例嗜酸细胞性滤泡 癌，2例均为女性，年龄分别为55岁、62岁，手术后无复发。肿瘤较大，直径约5cm和8cm，有包膜，实性。组织学，瘤细胞大 小形态较一致，核圆形或卵圆形，核异形不明显，核分裂罕见，丰富的嗜酸性胞质为其特征。两者的鉴别主要点是有无包膜 和／或血管浸润。良性和恶性嗜酸细胞性肿瘤均表达TG、vimentin、S一100，CEA。结论 甲状腺嗜酸细胞性肿瘤的临床病理和 免疫组织化学特点与甲状腺其他相对应类型的肿瘤相似。 [关键词】甲状腺；嗜酸细胞性腺瘤／癌；包膜；鉴别诊断 【中图分类号】R736．1 [文献标识码】A [文章编号】1673—9701(2008)O1—44—02 Hurthle Cell(oxypbilic)Tumors of Thyroid：A Clinicopathological Study WANG Xianxing P【，Yanwu WANG Dong ZHOU Bo ZHAI Lifang Department of Pathology，25th Hospital of PIA，Jiuquan 735000 【Abstract】Objective To improve one’s knowledge of the clinicopathological characteristics，the diagnosis and differential diagnosis of Hurthle cell ttlmors(HCT)of the thyroid，and to decrease the rate of misdiagnosis．Methods Two cases of huahle cell tunnots was studied with ctinicopathologic data and immunohistochemicM techniques，and also with review of the literature．Results There Was one case of the Turthle cell adenomas，one Hurthle cell follicular carcinomas．Two patients were young aduh females，35 and 43 years in age without recurrence after tumor resection．Th e tumors were larger in size，diameter 5cm and 8cm， all encapsulated and solid． Histologically a uniform population of cell Was seen．The nuclei were oval，round without alypia，and rate of mitotic activity Was evident，the tumor cell was characterized by abundant oxyphilic cytoplasm，differential diagnosis huahle carcinoma with capsular and vascular invasion．Immunostmns showed that almost all benign and malignant HCT expressed TG，vimentin，S-100 protein，CEA positive staining Was seen in most Hurthle cell adenomas and carcinomas．