西咪替丁（cimetidine）.doc

西咪替丁（cimetidine） The anti-digestive tract tumor of cimetidine Literature review of the world Chinese digestive journal article 6, 1998 Author: xu jiayu wu yunlin Unit: Shanghai second medical university ruijin hospital digestive section Shanghai 200025 Keywords: cimetidine/pharmacology; Digestive system tumor/drug therapy; Gastric tumor/drug therapy Effect of Cimetidine against digestive tract infection Zhu Q, Si F, Xu JY, Wu YL Subject headings cimetidine/pharmacology; Digestive system Neoplasms/drug therapy; Stomach neoplasms/drug therapy China book data classification number R 735 1 mechanism Until now, cimetidine for tumor and the function of the host of the exact mechanism is not fully clear. Relevant studies suggest that it may be the important mechanism of the anti-tumor by strengthening the functions of the parts of the immune system to play the role of immune regulation. Specific inhibitory to inhibit T lymphocyte cells (Ts) function, strengthen the helper T lymphocytes (TH) cells produce interleukin (IL - 2), and to promote the activity of natural killer cells (NK cells), etc., thus improve the bodys immunity and antitumor [1, 2]. Many tumor cells and tumor tissue infiltration of mast cells in the Histamine (Histamine) produce ability enhancement, and Histamine has proved to be a kind of digestive tract tumor growth factor, so this change will be beneficial to cancer cell growth and metastasis, as one of the escape immune surveillance and killing mechanism [3, 4]. In addition, the increase of histamine also has close relationship with the bodys immune function damage. If the immunosuppressive effect of histamine including silk to crack the hyperplasia of the reaction, the production of IL - 2 and lymphocytes, monocytes, and inhibition of cell activity of NK cells, etc., cimetidine and H2 receptor antagonist, histamine role to restore or part of a restore immune response and immune cell activity [1, 3]. Hahm et al. [2] compared the patients with gastric can