脆性组氨酸三联体和Ki67 蛋白在卵巢上皮性肿瘤组织中 - 航空总医院.PDF

2006 5 3 9 CH IN J CANCE R PREV TREAT , May 2006, Vol. 3 No. 9 # 669 # ×临床研究Ø Ki67 高国兰, 聂春莲, 高玟, 邹学森 江西省肿瘤医院妇产科, 江西 南昌330029 Study onexpression and clinical significance of FHIT and Ki67 protein in primary epithelial ovariantumor GA O Guo-lan, NIE Chun-lian, GA O Wen, ZO UX ue-sen Dep artment of Obstetrics G necolog , J iangx i P rovince Cancer H osp ital , N anchang 330029, P. R. China = : 探讨脆性组氨酸三联体 [ABSTRACT] OBJECTIVE: To investigate the expressions and correla- ( fragile histidine triad, FHIT) 和 Ki67 蛋白 tion of fragile histidine triad and Ki67 protein in primary epithelial ovarian 在卵巢上皮性肿瘤组织 的表达及临床意 tumor.METHODS:Expressions of FHIT and Ki67 proteins in primary o- 义: 采用免疫组化方法检测40 例卵 varian epithelial tumors( malignant n= 40, borderline tumor n= 20, benign 巢原发性上皮性癌20 例卵巢交界性肿瘤 adenoma n= 20) were evaluated by the immunohistochemical stain. RE- 和20 例卵巢良性腺瘤组织 FHIT 和Ki67 SULTS: Expression of FHIT protein in primary epithelial ovarian cancers 蛋白的表达: 卵巢上皮性癌 FHIT ( 65% , 26/ 40) was significantly lower than that in ovarian borderline 蛋白阳性率为65% (26/ 40) , 明显低于交界 tumors(95% , 9/ 20) , P = 01 0 2, and ovarian benign adenoma ( 00% , 性肿瘤 95% ( 9/ 20) 和良性肿瘤 00% 20/ 20) ,P = 01 0021 Ki67 protein was detected positive in 65% ( 26/ 40) of ( 20/ 20) , P 值分别为 01 0 2 和 01 002; 而 the epithelial ovarian cancers,which was significantly higher than that in o- Ki67 蛋白阳性率为65% (26/ 40) , 明显高于 varian borderline tumor (0, 0/ 20) , and ovarian benign adenoma(0, 0/ 20) , 交界性肿瘤0( 0/ 20) 良性肿瘤0( 0/ 20)