厄贝沙坦临床应用中国专家共识(讨论稿)（Consensus of Chinese experts on clinical application of irbesartan (discussion paper)）.docVIP

厄贝沙坦临床应用中国专家共识(讨论稿)（Consensus of Chinese experts on clinical application of irbesartan (discussion paper)） Consensus of Chinese experts on clinical application of irbesartan (discussion paper) Angiotensin receptor blocker (ARB) is an important cardiovascular drug, and has been widely used in clinic. More and more studies show that these drugs have good effects in the treatment of hypertension, heart failure and kidney diseases, so that their clinical status has been further consolidated. Irbesartan is a representative class ARB drug. It has accumulated a great deal of evidence in evidence-based medicine in recent years. To further standardize the clinical application of Maher Bbe Chatain, give full play to its role in prevention and treatment of cardiovascular diseases, in the international medical foundation in cooperation with the Senauer Faye Ann Wandt company, invite relevant experts and research data refer to fully acquired at home and abroad in recent years, jointly formulate the consensus. 1. Renin angiotensin system (RAS) and cardiovascular diseases RAS is one of the most important humoral regulation systems in the cardiovascular system. It is closely related to the pathophysiology, pathogenesis and development of hypertension, coronary heart disease, heart failure and renal impairment. Angiotensin II (AngII) is the most important vasoactive substance of RAS and exerts cardiovascular activity by binding with its receptor. AngII receptors are divided into four subtypes, namely AT1, AT2, AT3 and AT4. The adverse effects of AngII on the cardiovascular system are mainly achieved by the AT1 receptor. Basic studies have shown that AngII binding with AT1 receptors can cause vasoconstriction, cell proliferation, matrix formation, inflammatory response and oxidative stress, aldosterone secretion, and endothelial dysfunction. Studies have shown that RAS is involved in the occurrence and development of many cardiovascular diseases, so it is considered as one of the mos