转录因子HOXB7在肝癌侵袭转移中的作用和其机制的研究.pdfVIP

指 导 小组成 员名 单 徐 映 副教授 杨 欣 荣 博 士 基 金 资助 : 国家 “十 一 五 ”重 点科 技 攻 关 项 目 (2008Z X IO002一022 ) ， 国家 自然 科 学 基 金 资助 项 目 ，8 1030038，8 107 166 1和 8 1000927 ) ，上海 科 委 基 金 资助 项 目 (06Q A 一40 12 ，07JC 140 10，06xD 14004 ，044 119608 ) ， 国家 重 点基础 研 究 发 展 计 划 (973 Program ，20 1IC B 50400 1) ，上 海 青 年 科 技 启 明星 计 划 基 金 (10Q H 1400 500 ) 。 目 录 英文缩 略词表 ···········································································…… 1 中文 摘 要 ·················································································……2 英文 摘 要 ·················································································……7 前言 ·······················································································…… 12 第一部分 H o x B 7 在不 同转移潜 能人肝癌细胞系及组织 中的表达情 况 摘 要 ·······················································································…… 14 前 言 ·······················································································……巧 材料 与 方法 ··············································································…… 16 结果 ·······················································································……23 讨 论 ·······················································································……26 第 二部 分 H o x B 7 对人肝 癌细胞系生物学功 能 的影 响及相关机制 的研 究 摘要 ·······················································································……28 前 言 ·······················································································……29 材料 与方法 ··············································································……30 结果 ·······················································，·······························… …38 讨 论 ·······················································································……48 第三部分 H o x B 7 在肝癌 组织 中的表达及其 与肝癌 临床病理特征和预后 的关系 摘要 ·······················