基于数据挖掘的治疗老年性痴呆中药组方配伍研究.pdf

2015 年5月第 22卷第5期 中国中医药信息杂志 ·41· 基于数据挖掘的治疗老年性痴呆中药组方配伍研究 林森,路杰,宋堃,陈宗福,姜森,潘春良,李学博,付先军 山东中医药大学信息管理学院,山东 济南 250355 摘要：目的 探讨历代医家临床治疗老年性痴呆的中药组方配伍规律。方法 以健忘、多忘、痴、呆为检 索词,检索 《中华医典》中相关文献,筛选方剂信息并进行标准化处理,构建数据库,通过频数分析及关联规则方 法挖掘方剂的中药组成和配伍规律。结果 共选出 449 首与治疗老年性痴呆相关的处方,涉及中药 682 味。方 中出现频次最高的单味药为人参(192),药对为人参、远志(182),3味药物组合为茯神、人参、远志(79),4味药 物组合为远志、人参、茯神、甘草(37),通过关联规则分析得出,人参-远志、人参-甘草、人参-茯神等为临床 治疗老年性痴呆的方剂中常用配伍。结论 历代医家治疗老年性痴呆选药以补益、安神药物为主,其配伍组合 合理,具有一定代表性。 关键词：老年性痴呆；用药规律；中医文献；数据挖掘 DOI：10.3969/j.issn.1005-5304.2015.05.012 中图分类号：R2-05；R277.2 文献标识码：A 文章编号：1005-5304(2015)05-0041-04 Study on Compatibility of TCM Prescriptions for Treating Alzheimer Disease Based on Data Mining LIN Sen, LU Jie, SONG Kun, CHEN Zong-fu, JIANG Sen, PAN Chun-liang, LI Xue-bo, FU Xian-jun (School of Information Management, Shandong University of TCM, Jinan 250355, China) Abstract ：Objective To study the compatibility of TCM prescriptions of TCM practitioners of all dynasties of Alzheimer disease (AD). Methods Amnesia, forgetting, dementia, and idiot were set as search words to retrieve relevant literature in Encyclopadia of Traditional Chinese Medicine. Prescription information was screened and standardized to build database. Frequency analysis and association rules were used to mine TCM prescriptions and compatibility rules. Results Totally 449 AD related prescriptions were selected, involving 682 Chinese medicinal herbs. The individual herb with the highest frequency was Ginseng Radix Rhizoma (192)；the herbal pair with the highest frequency was Ginseng Radix Rhizoma-Polyhalae Radix (182) ；the herbal combination with 3 Chinese medicinal herbs with the highest frequency was Poria with Hostwood-Ginseng Radix Rhizoma-Polyhalae Radix (79)；the