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Assessment of renal autoregulation - Renal (评估肾自动调整肾)
Am J Physiol Renal Physiol 292: F1105–F1123, 2007.
First published January 16, 2007; doi:10.1152/ajprenal.00194.2006. Invited Review
Assessment of renal autoregulation
William A. Cupples1 and Branko Braam2
1Centre for Biomedical Research, Department of Biology, University of Victoria, Victoria, British Columbia;
and 2Departments of Medicine and Physiology, University of Alberta, Edmonton, Alberta, Canada
Cupples WA, Braam B. Assessment of renal autoregulation. Am J Physiol
Renal Physiol 292: F1105–F1123, 2007. First published January 16, 2007;
doi:10.1152/ajprenal.00194.2006.—The kidney displays highly efficient autoregu-
lation so that under steady-state conditions renal blood flow (RBF) is independent
of blood pressure over a wide range of pressure. Autoregulation occurs in the
preglomerular microcirculation and is mediated by two, perhaps three, mechanisms.
The faster myogenic mechanism and the slower tubuloglomerular feedback con-
tribute both directly and interactively to autoregulation of RBF and of glomerular D
o
capillary pressure. Multiple experiments have been used to study autoregulation w
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