三七皂苷缓释微球的性质研究.PDFVIP

·药 剂 · 三七皂苷缓释微球的性质研究 1 1 1 1 1 2 赵国巍 ，廖正根 ，陈绪龙 ，梁新丽 ，王光发 ，蒋且英 (1.江西中医学院现代中药制剂教育部重点实验室，南昌 330004 ； 2.江西中医学院成人教育学院，南昌 330006) 摘要：目的 对三七皂苷缓释微球(PNS-SRM)的理化性质进行研究。方法 采用粒径测定、扫描电镜(SEM)、比表面积测 定、差示扫描量热分析(DSC)、红外光谱(IR)、X 射线衍射(XRD)、溶出度测定等手段研究 PNS-SRM 的理化性质。结果 PNS-SRM 与物理混合物相比，在 IR、DSC 、XRD 上有显著差异。PNS-SRM 具有明显的缓释效应。结论 PNS-SRM 中 壳聚糖、丙烯酸树脂和三七皂甘(PNS)之间发生了分子间作用，有新晶形生成。 关键词：三七皂苷；缓释微球 中图分类号：R943.41 文献标志码：B 文章编号：1007-7693(2010)11-1112-04 Study on the Properties of Panax Notoginseng Saponins Sustained Release Microspheres 1 1 1 1 1 2 ZHAO Guowei , LIAO Zhenggen , CHEN Xulong , LIANG Xingli , WANG Guangfa , JIANG Qieying (1.Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; 2.College of Adult Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China) ABSTRACT: OBJECTIVE To study on physicochemical properties of Panax notoginseng saponins sustained release microspheres (PNS-SRM). METHODS Some analytical methods, such as determination of particle size, scanning electron microscopy (SEM), differential thermal analysis (DSC), infrared spectra (IR), X-ray powder diffraction (XRD), specific surface area determination, dissolution test, were applied to the investigation of PNS-SRM. RESULTS There were difference between PNS-SRM and physical mixture in IR, DSC, XRD. The PNS-SRM had good slow releasing effect. CONCLUTION There is intermolecular interaction among chitosan, acrylic resin and PNS in PNS-SRM. In the PNS-SRM a new crystal form was generated. KEY WORDS: Panax notoginseng saponins