化学专业英语摘要翻译6篇.docx

Asymmetric C(sp)-C(sp2) bond formation to give enantiomerically enriched 1,3-butadienyl-2-carbinols occurred through a homoallenylboration reaction between a 2,3-dienylboronic ester and aldehydes under the catalysis of a chiral phosphoric acid (CPA). A diverse range of enantiomerically enriched butadiene-substituted secondary alcohols with aryl,heterocyclic, and aliphatic substituents were synthesized in very high yield with high enantioselectivity. Preliminary density functional theory (DFT) calculations suggest that the reaction proceeds via a cyclic six-membered chairlike transition state with essential hydrogen-bond activation in the allenereagent.The catalytic reaction was amenable to the gram-scale synthesis of a chiral alkylbutadienyl adduct, which was converted into an interesting optically pure compound bearing a benzo-fused spirocycliccyclopentenone framework.在手性磷酸（CPA）催化剂条件下，2,3-硼酸酯和醛通过反应生成了富对映体的1,3-丁二烯-2-甲醇，这里面含有不对称的碳（sp杂化）碳（sp2杂化）键。不同丁二烯取代的二级醇的富对映体和芳香烃、杂环以及脂肪烃的合成可以有高产率和很好的对映体选择性。初步的密度泛函理论（DFT）的计算表明，这个反应是在丙二醇试剂中通过对氢键必要的活化而经过了一个六元环椅型结构的过渡态实现的。这个反应对于手性的烷基二烯的克级别反应而言是容易控制的，而手性的烷基二烯可以转化为一种有趣的耐苯并环戊酮的光学纯化合物。YiyongHuang,Xing Yang,ZongchaoLv,ChenCai,Cheng Kai, Yong Pei,and YuFeng. Asymmetric Synthesis of 1,3-Butadienyl-2-carbinols by the Homoallenylboration of Aldehydes with aChiral PhosphoricAcidCatalyst[J].AngewandteChemie,2015,127:7407-7410C-H bonds are ubiquitous in organic compounds. It would, therefore, appear that direct functionalization of substrates by activation of C-H bonds would eliminate the multiple steps and limitations associated with the preparation of functionalized starting materials. Regioselectivity is an important issue because organic molecules can contain a wide variety of C-H bonds. The use of a directing group can largely overcome the issue of regiocontrol by allowing the catalyst to come into proximity with the targeted C-H bonds. A wide variety of functional groups have been evaluated for use as directing groups in the transformation