丹红注射液治疗2型糖尿病下肢血管病变临床探究.docVIP

丹红注射液治疗2型糖尿病下肢血管病变临床探究 【摘 要】 目的 观察丹红注射液治疗2型糖尿病下肢血管病变的疗效。方法 选择2型糖尿病合并下肢血管病变患者64例，均予常规治疗,随机分为治疗组32例和对照组32例，分别加用丹红注射液20 ml/d，和丹参注射液20 ml/d，共4周。观察治疗前后血糖、血脂、糖化血红蛋白、血丙氨酸氨基转移酶、血尿素氮、血肌酐，股动脉、?动脉、足背动脉内径与血流速度等指标的变化。结果 治疗组总有效率71．8%，对照组50%,两组疗效比较差异有非常显著意义(P＜0．01)。治疗组股动脉、?动脉内径与血流速度较治疗前显著改善(P＜0．01)，足背动脉内径与血流速度较治疗前虽有改善，但差异无统计学意义(P＞0．05)。对照组各动脉内径与血流速度与治疗前比较，差异无统计学意义(P＞0．05)。治疗中无严重不良反应发生。结论 丹红注射液能扩张下肢血管，有助于糖尿病下肢血管病变的治疗。 ?【关键词】 丹红注射液;2型糖尿病;下肢血管病变 Effects of Danhong injection on Type-2 diabetic patients with lower limb angiopathiesZHANG Jian-de，TANG Wen-long，WU Zhong-ming，et al．Department of Endocrinology，Guilin Hospital of Traditional Chinese Medicine，Guilin 541002，China?【Abstract】 Objective To investigate the efficacy of Danhong injetion on lower limb angiopathies in diabetic patients．Methods 64 diabetic patients with lower limber angiopathies were divided into control group (32 patients，regular therapy+Salivia Miltiorrhiza injetion) and treatment group(32 patients，regular therapy+Danhong injection) with a course of 4 weeks treatment．Before and after treatment，inner diameter of the femoral artery，popliteal artery，dorsal pedal artery and blood current velocity degree of lower extremity were measured by Doppler,together with the determination of hepatic and renal functions，serum low density cholesterol，total cholesterol and triglyceride．Results After the treatment，The total efficacy rates reached 71．8%and 50%in the treatment and control groups respectively but with obvious significance (P＜0．01)．?The inner diameters of the femoral artery，popliteal artery and blood current velocity of lower extremity were improved significantly in the treatment group(P＜0．01)，while the inner diameter of dorsal pedal artery and blood current velocity did show some improvement but without significant difference(P＞0．05)．The inner diameters of each artery and blood current velocity in the control group did not change obviously after treatment (P＞0．05)．No remarkable adverse reactions occurred during th