早、晚服用施慧达对原发性高血压疗效比较.docVIP

早、晚服用施慧达对原发性高血压疗效比较【摘要】 目的 评价早、晚服用施慧达对原发性高血压的降压疗效及毒副反应。方法 将原发性高血压患者68例随机分为两组（分别命名为晨组与晚组），按2．5~5．0 mg/d剂量分别于早餐或晚餐0．5 h后口服施慧达4周，观察治疗前后降压疗效。结果 与治疗前相比，两组对原发性高血压均具有显著降压效果，总有效率分别为85%、86%，但组间比较无统计学差异，两组中均未见有不良事件的发生。结论 早、晚服用施慧达对原发性高血压均具有良好的降压效果，且均不易发生不良事件。 【关键词】施慧达；原发性高血压；血压 Effects of taking levamlodipine in the morning and night on primary hypertension LI Ling-ling,LI Jing,ZHAO Shu-qing.2nd Medical Department,Qianwei Hospital of Jilin Province,Changchun 130012，China 【Abstract】 Objective To investigate the effects of Shihuida (levamlodipine) taken in the morning or night on primary hypertension.Methods 68 primary hypertension patients were divided into 2 groups randomly (named as morning group and night group respectively).Shihuida was taken orally at a dose of 2．5-5．0 mg/d 0．5 h later after breakfast or dinner everyday during four weeks and its depressurization effect was examined after treatment.Results The results showed that taking Shihuida either at morning or evening could significantly lower patients’ blood pressure,which the total effective rates was 85%，86% respectively,no significant differences were observed between the 2 groups,however.It was also showed that no side-effect occurred during our treatment period.Conclusion Taking Shishuida both in the morning or evening can significantly decrease blood pressure of primary hypertension patients without side-effect. 【Key words】Shihuida;Primary hypertension;Blood pressure 施慧达（苯磺酸左旋氨氯地平）为二氢吡啶类长效钙离子拮抗剂，属于WHO/ISH 推荐的六类一线降压药物之一，能有效阻滞钙离子通过“慢”通道流入血管平滑肌细胞，从而产生血管舒张效应[1]，可用于各种程度高血压的治疗。笔者用施慧达对68例中度原发性高血压患者进行治疗，观察了早、晚两个时间点服用该药的降压效果及发生心悸、头痛、头晕、面色潮红、下肢浮肿等不良反应的例数。 1 资料与方法 1．1 一般资料 根据1999年WHO/ISH血压诊断标准，选择我院门诊确诊的2级原发性高血压患者68例，年龄30~55岁，平均45岁，男39例,女 29例；病程 6 个月～10 年。经体格检查和血常规、肝功能、肾功能、电解质、胸片、心电图、腹部B 超检查，排除继发性高血压和严重的心脑、肾并发症患者。 1．2 研究方法 入选患者受试前停用一切抗高血压药物并且服用安慰剂 1 周。将患者随机分为晨组(34例) 和晚组（34例），在08:00~10:00安静状态下用台式水银柱血压计测诊室坐位同侧上臂血压 3 次，取均值。治疗开始后每天分别于早餐或晚餐0．5 h后口服苯施慧达2．5 mg/d，每周五同一时间段内复查，特别注意有无不良事件的发生。 如服药第2周末血压仍未得到控