早发冠心病患者危险因素临床探究.docVIP

早发冠心病患者危险因素临床探究【摘要】 目的 探讨早发冠心病患者的危险因素特点。方法 152例经冠状动脉造影确诊的冠心病患者，根据年龄分为早发冠心病组（男＜55 岁，女＜65岁）74例和对照组78例。对两组患者的相关资料进行回顾性统计分析，比较二者的血脂水平、高血压病史、糖尿病病史、冠心病家族史、吸烟史、饮酒史等，评价在两组人群间是否存在差异性。结果 早发冠心病组中吸烟史，冠心病家族史，血清总胆固醇高于老年冠心病组；而高血压病史、糖尿病史低于老年冠心病组。结论 早发冠心病患者吸烟、冠心病阳性家族史，高胆固醇血症是主要的危险因素。 Clinical study on the risk factors of patients with premature coronary heart disease LIU Zhi-yuan， LI Yu-dong, LI Gang, et.al. Department of Cardiology，Nanyang central Hospital，Nanyang473009,China 【Abstract】 Objective To investigate the risk factors of patients with premature coronary heart disease. Methods Coronary angiography was done in 152 coronary heart disease（CHD）patients were devided into two groups by age.74 patients with premature CHD（male＜55 year-old, female＜65 year-old）were compared with 78 patients with gerontism CHD.The risk factors of premature CHD were illustraled.Results The percentage of smoking and family history of CHD were higher in patients with premature CHD than those in patients with gerontism CHD. But the patients with premature CHD had lower rate of hypertension and diabetes compared with the patients with gerontism CHD.Patients with premature CHD had higher levels of serum total cholesterol（TCH）and low-density lipoprotein cholesterol（LDL-C）compared with the patients with gerontism CHD. Conclusion Smoking，family history of CHD，hypercholesterolemia are important risk factors for patients with premature CHD. 【Key words】 Coronary heart disease; Coronary artery; Risk factors 早发冠心病是指冠心病发生时男＜55岁，女＜65岁［1］，是冠心病的一种特殊形式。由于早发冠心病在预后、寿命和劳动力丧失、生活质量及医疗费用等方面的损失均大于晚发冠心病。因此，研究早发冠心病的危险因素，对于开展有针对性的人群预防，延缓或防止冠心病的发生具有重要的社会经济效益。本文旨在通过对早发冠心病患者主要危险因素的研究，为冠心病的早期防治提供临床帮助。 1 资料与方法 1.1 一般资料 均为南阳市中心医院住院的冠心病患者共152例。所有的患者均有完整的病历资料。根据年龄（男55岁，女65岁）分为两组，早发冠心病组（男＜55 岁，女＜65岁）74例，其中男52例，女22例，年龄37～64（49.85±6.59）岁。对照组78例，其中男53例，女25例，年龄56～79（67.74±5.59）岁。排除标准：肝肾功能不全、甲亢、Cushing综合征等自身免疫性疾病或结缔组织性疾病者、合并感染、肿瘤等疾病者。 1.2 研究方法 1.2.1 冠心病危险因素筛选 所有资料均来源于住院患者的原始资料。危险因素以性别、吸烟、饮酒、高血压、高血脂、糖尿病、冠心病家族史为主。①吸烟史［2］