陕北地区无症状女性人群HPV感染现状及相关因素 - 第三军医大学学报.DOC

陕北地区无症状女性人群HPV感染现状及主要型别分析 张静1，霍满鹏1，慕明涛1，刘俊俊1，赵君梅2 （1、延安大学医学院，陕西延安，716000；2、陕西延安中学，陕西延安，716000） 【摘要】 目的：明确陕北地区无症状女性宫颈HPV感染现状及主要型别分析，寻找地区特异性HPV型别。方法：利用结构式、回顾性问卷调查获取流行病学信息。通过研究对象的宫颈脱落细胞进行HPV分型检测，结果进行(2检验分析。结果：共收集到来自陕北地区两市6个县区共3685例宫颈脱落细胞样本。逐一检测后，总HPV感染率为13.8%，高危型HPV感染率为10.6%。感染率最高的为HPV 16(3.05%)，其次是HPV 52(2.9%)和HPV 58(2.4%)。被检测人群中，HPV 16和-18占4.26%。结论：陕北地区无症状女性人群中，第一代疫苗相关型别的感染率得到了很好的控制，感染率相对较低，但HPV 52及-58两型别的感染率相对较高。因此，第二代预防性疫苗应包含HPV 52和-58，以致达到更高几率的保护。 【关键词】HPV；流行病学；危险因素 Prevalence and the Main Type of HPV Infection in Asymptomatic General Female Population in Shanbei District ZHANG Jing et al Medical of yan’an university yan’an 716000 [Abstract] Objectives:To be explicit of cervical HPV prevalence, as well as the main type of HPV analysis to find region-specific HPV types in asymptomatic general female population in shanbei district. Methods: Through the form of structured and retrospective clinical epidemiological questionnaire was used to collect epidemiologic data and the cervical sampler was used to collect exfoliated cervical cells for HPV genotyping, statistical analysis was performed using (2 test. Results: 3685 cases of cervical cell samples were collected from six counties of shanbei district. After each test, the overall HPV prevalence was 13.8%, HR-HPV prevalence was 10.6%. HPV-16 was the most common type (3.05%)，followed by HPV-52 (2.9%), 基金项目：陕西省科学技术研究发展计划项目（2011K13-02-06）；陕西省教育厅专项科研计划项目（2010JK911）；陕西省卫生厅卫生科研基金项目（2010H24）；延安市科技发展计划项目（2009KS-14）；延安大学2010年自然科学专项科研基金项目（YD2010-06）；延安大学2011年自然科学专项基金项目（YD2011-05）。 HPV-58 (2.4%). HPV-16and-18 were present in 4.26%of the detected samples. Conclusions: The first generation of vaccine-associated type infection has been well controlled in asymptomatic female population in shanbei district, relatively low rate of infection.However, HPV 52 and -58 relatively high prevalence.Therefore, Second-generation preventive vaccine should contain HPV 52 and -58, in order to achieve a higher protection for women in this area.