糖皮质激素药理作用（Glucocorticoid pharmacological action）.doc

糖皮质激素药理作用（Glucocorticoid pharmacological action） Glucocorticoid pharmacological action Anti-inflammatory glucocorticoids have a powerful anti-inflammatory effect, which can be used to counter inflammation caused by various causes: physical injury, such as burns, trauma, etc. (2) chemical damage, such as acid, alkali injury, (3) biological damage, such as bacteria, virus infection, (4) immunity damage, such as various types of allergy, 5 aseptic inflammation, such as ischemic tissue damage. Early in a variety of acute inflammation, application of glucocorticoid can reduce inflammation early exudation and edema, blood capillary dilate, leukocyte infiltration and devour reaction, thus improving inflammation early clinical symptoms such as redness, swelling, heat, pain. In the late inflammation, application of glucocorticoid can inhibit the proliferation of capillaries and fibroblasts, inhibit the synthesis of collagen and glycosaminoglycan and granulation tissue hyperplasia, preventing inflammation adhesion and scar formation, in the late sequela of reduce inflammation. But must pay attention to, inflammation is the body of a defense function, inflammatory reaction and is an important process of tissue repair in the late, so the glucocorticoid in inhibiting inflammation, relieve symptoms, at the same time, also reduces the bodys defense and repair function, spread can lead to infection and delayed wound healing. Immunosuppression and allergy in many ways the glucocorticoid on the immune response inhibition, can alleviate the symptoms of many allergic diseases, the pathological changes of the inhibition caused by an allergic reaction, such as allergic congestion, edema, exudation, skin rashes, smooth muscle spasm and cell damage, inhibit tissue organ transplant rejection, for autoimmune diseases can also play a recent curative effect. Immunological inhibition of glucocorticoid was related to the following factors: inhibition of phagocytic phagocytic phagocytosis and tre