酵母菌合成2-苯乙醇的研究进展.PDFVIP

生 物 工 程 学 报 陈先锐 等/酵母菌合成2-苯乙醇的研究进展 1151 Chinese Journal of Biotechnology /cjbcn September 25, 2016, 32(9): 1151−1163 DOI: 10.13345/j.cjb.150539 ©2016 Chin J Biotech, All rights reserved 综 述 2- 陈先锐，王肇悦，何秀萍 100101 , , . 2-. , 2016, 32(9): 1151–1163. Chen XR, Wang ZY, He XP. Advances in biosynthesis of 2-phenylethanol by yeasts. Chin J Biotech, 2016, 32(9): 1151–1163. 摘 要: 2-苯乙醇是一种具有令人愉悦的玫瑰风味的芳香醇，在食品、化妆品和药品等领域具有广泛的应用。 本文对酵母菌合成2-苯乙醇的代谢途径及其调控过程、以及提高2-苯乙醇产量的国内外研究进展进行了综述， 并对通过微生物转化法合成2-苯乙醇目前存在的不足及进一步研究方向进行了讨论。 : 酵母，2-苯乙醇，代谢途径，基因，调控 Advances in biosynthesis of 2-phenylethanol by yeasts Xianrui Chen, Zhaoyue Wang, and Xiuping He CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Abstract: 2-Phenylethanol (2-PE) is an aromatic alcohol with a pleasant rose-like fragrance. It has been widely used in food, cosmetic, and pharmaceutical industry. Most of 2-PE is produced by chemical synthesis, but the use of chemically synthesized product is restricted in some fields. 2-PE from plant extraction is natural but its production is very low. Microbial biotransformation is a promising process to produce natural 2-PE. In this paper, we review recent research progress in the synthetic metabolic pathways and regulatory processes of 2-PE in yeast, and strategies for improving 2-PE production. Moreover, we discuss the limitation of current progress and future research directions. Keywords: yeast, 2-phenylethanol, metabolic pathway, gene, regulation 2- (2-Phenylethanol 2-PE)β-