Critical overview of Nitinol surfaces and their ...（关键的概述镍钛诺表面和他们）.pdf

Available online at Acta Biomaterialia 4 (2008) 447–467 /locate/actabiomat Review Critical overview of Nitinol surfaces and their modifications for medical applications S. Shabalovskaya a,b,*, J. Anderegg b, J. Van Humbeeck a a Katholieke Universiteit Leuven, MTM Kasteelpark Arenberg 44, B-3001 Leuven, Belgium b Ames Laboratory, Ames, IA 50011, USA Received 18 July 2007; received in revised form 16 November 2007; accepted 10 January 2008 Available online 6 February 2008 Abstract Nitinol, a group of nearly equiatomic shape memory and superelastic NiTi alloys, is being extensively explored for medical applica- tions. Release of Ni in the human body, a potential problem with Nitinol implant devices, has stimulated a great deal of research on its surface modifications and coatings. In order to use any of the developed surfaces in implant designs, it is important to understand whether they really have advantages over bare Nitinol. This paper overviews the current situation, discusses the advantages and disad- vantages of new surfaces as well as the limitations of the studies performed. It presents a comprehensive analysis of surface topography, chemistry, corrosion behavior, nickel release and biological responses to Nitinol surfaces modified mechanically or using such methods as etching in acids and alkaline solutions, electropolishing, heat and ion beam tre