前列腺癌与雄激素受体基因_CAG_n重复多态性的关系.pdf

2002 6 23 6 Ch in J Urol, Jun 2002, Vol 23, No. 6 # 351 # ## ( CAG) n 王钢 陈光椿 王晓慧 夏冰 张金山 卢建 = ( PC) ( AR) ( CAG) n DNA 34 PC 2 PC A R ( CAG) n PC ( CA G) n ; 36 A R ( CAG) n , 20. 06, , (P 0. 05) ; ( CAG) n ( P 0. 05) A R ( CAG) n PC , PC = ; ; , ; Studyonthe polymorphism of (CAG) n repeats within androgen receptor gene in patients with prostate cancer WANG Gang, CHEN Guangchun, WANG Xiaohui, et al. Department of Pathophysiology, Second illitary edical University , Shanghai 200433,China = Abstract Objective T o study t h r lationship b tw n polymorphic ( CAG) n r p ats of androg n r c ptor( A R) g n and occurr nc of prostat canc r ( P C) . Methods ( CA G) n r p ats of both malig- nant c lls and adjac nt nonmalignant c lls from 34 paraffin- mb dd d PCs, and that of p riph ral blood c lls from 2 PC pati nts w r ass ss d using dsDNA cycl s qu ncing. Results Th numb r of ( CAG) n r - p ats in malignant c lls w as qual to that in adjac nt nonmalignant c lls from th sam paraffin- mb dd d PC; th m an of ( CAG) n r p ats in th 36 P C pati nts was 20. 06 w hich w as significantly small r than t hat of normal m n ( P 0. 05) , although no significant diff r nc in t h polymorphic distribution of ( CA G) n was found among various grad s of PC ( P 0. 05) . Conclusions Short ning of ( CAG) n r - p ats w ithin AR g n may b associat d with th occurr nc of PC. = ey words Prostat n oplasms; Carcinoma; R c ptor, androg n; G n s ( PC) , PC ( AR) PC AR X q11-12AR , 8 7 32 C- P-ATP , ( CAG) n /