替莫唑胺在肿瘤化疗中的应用进展.PDF

中国现代神经疾病杂志 年 月第 卷第 期 ·1044 · 2013 12 13 12 ChinJContempNeurolNeurosurg,December2013,Vol.13,No.12 综述 · · 替莫唑胺在肿瘤化疗中的应用进展 钟诚 王彬 吕胜青 【 】 替莫唑胺作为一种新型咪唑四嗪类烷化剂，在中枢神经系统肿瘤，特别是恶性胶质瘤化疗 摘要 中得到广泛应用，成为胶质瘤化疗进展的“里程碑”。近年来研究者们也开始试用该药治疗其他肿瘤，有 些研究业已取得了较好的疗效，如黑色素瘤和颅内转移瘤，还将其应用于原发性中枢神经系统淋巴瘤、 难治性白血病、垂体肿瘤和肺癌等良、恶性肿瘤的化疗。本文拟对替莫唑胺的抗肿瘤作用机制、在胶质 瘤中的应用和其他一些非常规适应证的应用及其疗效进行概述。 【 】 神经胶质瘤； 替莫唑胺（非 词）； 综述 关键词 MeSH Applicationprogressoftemozolomideinclinicaltumorchemotherapy 1 1 2 ZHONGCheng ,WANGBin,LVSheng⁃qing 1Department of Neurosurgery, Yongchuan Peoples Hospital, Chongqing 401000, China 2Department of Neurosurgery, Xinqiao Hospital, the Third Military Medical University of Chinese PLA, Chongqing 400037, China Corresponding author: WANG Bin (Email: wangwb_66@); LV Sheng qing (Email: lvsq0518@) ⁃ 【 】 Abstract Temozolomideisanimidazotetrazinederivativeofthealkylatingagent,whichisusedto treat central nervous system tumors, especially malignant brain gliomas. Itis a milestone in brain giloma chemotherapy. Recently,some researchers used temozolomideforthetreatmentofothertumors,including melanoma, intracranial metastatic tumors, lymphomas, refractory leukaemia, pituitary tumors, lung cancer, and so on. Some results are encouraging in clinical trials. Here, this paper makes a review on the antineoplasticmechanismsoftemozolomide,itsindicationsingliomasandsomeunusualindications. 【 】 MeSH Keywords Glioma; Temozolomide (notin ); Review This study was supported by National Natural Science Foundation of China (No., Natural