可待因及羟考酮、右丙氧芬复方制剂依赖性的流行病学调查.pdfVIP

(Chin J Drug Depend)2004, 13(3):213-216 ·213 · [] 可待因及羟考酮、右丙氧芬复方制剂 依赖性的流行病学调查 刘锐克　孙桂宽　穆　悦　连　智　郭　平　刘志民＊ (, , 100083) 　目的:7 、()。 方法: “”“”, “、”, 、、21。 结果:3910 。7VAS 0.00-0.04 ;, , OWS 0.00-0.09 ;7 。 结论: ;。 　;; EPIDEMIOLOGICAL INVESTIGATION OF CODEINE CO.QXYCODONE CO. AND PROPOXYPHENE CO.DEPENDENCE ＊ LIU Ruike, SUN Guikuan, MU Yue, LIAN Zhi, GUO Ping, LIU Zhi in (National Institute on Drug Dependence, Peking University ,Beijing, 100083 ) ABSTRACT　Obj ective:To investigate the drug produced dependence potential of the 7 co pounds of codeineor oxycodone or propoxyphene (codeine Co.)Met ods:Clients who used codeine Co.at least for 7 days were surveyed retrospectively or intensively at hospitalbase.Physical dependence and psychic dependence were assessedwith Opiate Wit drawal Scale (OWS)and VisualAnalogue Scale (VAS), respectively.Results: The survey was conducted in 3910 cases fro Beijing, Shanghai, Tianjin and Nanchang.The ean ti e of unceasing useof each codeine Co.was ore than 17 days.The ain purpose of codeine Co.ad inistration was for analgesia.Most clients encountered nowithdrawal syndro eafter stopping codeineCo.use.TheOWS scorewas between 0.00-0.09.The psychicdependence assessed byVASwas low.The averagedaily dosage of codeine Co.increased as the use prolonged, showing a significant difference co paredwith the initial dose (t=16.514-23.698, P =0.000).Conclusion:CodeineCo.shows a little dependence producing potential for edical use, but the tolerance is significant. KEY WORDS　codeine co pounds;drug dependence;epide iological investigation 　　、( , )20 90 , , , 2002 5 -2003 7 “”。 , 。