阿霉素靶向给药系统研究进展.pdf

PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 12 :910-915 910 ( ) 阿霉素靶向给药系统研究进展 1 2 3 1* 4** 李进典 ，洪杏芳 ，张健 ，殷志琦 ，顾觉奋 （1. 中国药科大学中药学院，江苏 南京 210009；2. 大理学院公共卫生学院，云南 大理 671000；3. 江苏省中医药研究院转化医学实验室， 江苏 南京 210028；4. 中国药科大学生命科学与技术学院，江苏 南京 210009） [ 摘要 ] 近年来，癌症的发病率和死亡率不断上升，对人类健康造成极大的威胁。阿霉素作为一种广谱抗肿瘤药物，对正常细胞亦有严重毒 副作用，从而使其临床应用受到限制。提高阿霉素肿瘤靶向性、降低其毒性由此成为该药物的热点研究方向。对阿霉素靶向给药系统的研 究进展进行了综述。 [ 关键词 ] 阿霉素；抗肿瘤；靶向给药系统 [ 中图分类号 ] R979.1 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2014）12-0910-06 Advances in Research on Targeting Drug Delivery System of Doxorubicin 1 2 3 1 4 LI Jindian , HONG Xingfang , ZHANG Jian , YIN Zhiqi , GU Juefen ( 1. School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China; 2. School of Public Health, Dali University, Dali 671000, China; 3. Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; 4. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China) [Abstract] In recent years, the morbidity and mortality of cancer have been rising, which has become a great threat to human health. Doxorubicin is a broad-spectrum antitumor drug. It also has serious side effects on the normal cells, which limits its clinical application. Increase tumor targeting effect and reducing the toxicity have become a hot research direction of this drug. The advances in research on targeting drug delivery system of doxorubicin have been reviewed in this paper. [Key words] doxorubicin; antitumor; targeting drug delivery system WHO 世界癌症研究中心全球监测数据显示：20