多粘菌素耐药性的研究进展.PDF

微生物学通报 Jan. 20, 2017, 44(1): 200−206 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.160272 专论与综述 多粘菌素耐药性的研究进展 1 2 3 3 3* 王影 李艳然 韩镌竹 高铎 李欣南 (1. 130118) (2. 110016) (3. 110016) 摘 要：多粘菌素因在多重耐药革兰氏阴性菌上的治疗效果良好，再度被应用于临床，其耐药 水平在多种抗菌药中曾一度较低，但目前有研究表明多粘菌素的耐药率有增加趋势。作为抗击 多重耐药革兰氏阴性菌的最后一道防线，如何抑制其耐药的发生就显得尤为重要。本文就多粘 菌素的耐药性现状、产生机制及防控措施三个方面进行了综述，为指导临床科学合理使用多粘 菌素及革兰氏阴性菌耐药菌株传播和蔓延的防控措施提供理论依据。 关键词：多粘菌素，耐药性，耐药机制，耐药抑制防范 Progress in drug resistance of polymyxin WANG Ying1 LI Yan-Ran2 HAN Juan-Zhu3 GAO Duo3 LI Xin-Nan3* (1. College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, China) (2. Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China) (3. Animal Products Quality and Safety Inspection Center of Liaoning Province, Shenyang, Liaoning 110016, China) Abstract: Because of its effectiveness in curing infections caused by multi-drug resistant Gram-negative bacteria, polymyxin is applied to clinic again. Its drug resistance is generally low among a variety of antibiotics. However, there are studies showing that the drug resistance of polymyxin increases. As the last resort for treating multi-drug resistant Gram-negative bacteria, the occurrence of polymyxin resistance is especially important. This article summarizes the present situation, the underlying mechanism and the counteracting