Hp感染及肝硬化相关性探究.doc

Hp感染及肝硬化相关性探究[摘要] 目的：探讨幽门螺杆菌( Hp) 感染对肝硬化患者肝功能相关指标的影响。方法：对73例肝硬化患者在检测肝功能[包括血清总胆红素、甲胎蛋白(AFP) 水平和血氨水平]同时进行胃镜检查和Hp感染情况检测，并根据功能分级。根据Hp感染情况分为Hp(+) 组和Hp(-)组。比较两组患者的血清总胆素、甲胎蛋白水平和血氨水平，进行相关性分析。结果：血清总胆素、甲胎蛋白(AFP) 水平和血氨组无显著性差异，但在Child-pugh分级C级患者中 Hp(+)组AFP水平和血氨水平明显高于Hp(-)组。结论：Hp感染可能是肝硬化患者AFP和血氨升高的一个原因，且Hp感染对肝硬化AFP、血氨的影响与其肝功能分级密切相关。 [关键词] 肝硬化；幽门螺杆菌；总胆红素；甲胎蛋白；血氨 [中图分类号] R575.2[文献标识码]Ａ [文章编号]1673-7210（2009）01（b）-038－02 The correlation between cirrhosis and helicobacter pylori infection in patientswith HB FENG Hong-jun, NIU Sheng-li, MI Cai-feng, ZHANG Can, CHEN Xiao-na (The First People’s Hospital of Pingdingshan City, Pingdingshan467000, China) [Abstract] Ｏbjective: To explore the effect of helicobacter pylori infection on liver function in patients with cirrhosis HB. Methods: Liver function(serum total bilirubin, AFP and blood ammonia) were detected in 73 patients with cirrhosis, and the gastroscopy and Hp detection were applied to the patients at the same time, and the patients were classified according to hepatic function. The patients were divided into two groups based on Hp detected: Hp(+) group and Hp(-) group. The correlation of liver function was analyzed between Hp(+) and Hp(-) group. Results: There were no differences between Hp(+) group and Hp(-) group of serum total bilirubin, AFP and blood ammonia. While AFP and blood ammonia of Hp(+) group was significantly higher than that of Hp(-) group in patients with the C grade in Child-pugh. Conclusion: Hp infection is probably one reason of AFP and blood ammonia increased in patients with cirrhosis, the effects of AFP and blood ammonia in the cirrhosis with helicobacter pylori infection are closed correlated to the classification of hepatic function. [Key words] Cirrhosis; Helicobacter pylori; Total bilirubin; AFP; Blood ammonia 自从1983年从胃黏膜标本中培养出幽门螺杆菌(helicobacter pylori，Hp)以来，发现许多疾病与Hp感染相关。本文通过观察Hp感染的不同肝功能分级的肝硬化患者各项指标，探讨幽门螺杆菌感染与肝硬化的关系。 1资料与方法 1.1研究对象 2004年12月～2006年7月，住院的73例肝硬化患者（男46例，女27例），年