加替沙星及左氧氟沙星治疗泌尿系统感染经济学研究.docVIP

加替沙星及左氧氟沙星治疗泌尿系统感染经济学研究[摘要] 目的：比较加替沙星与左氧氟沙星治疗泌尿系统感染的成本-效果分析。方法：采用药物经济学原理对两种治疗方案进行成本-效果分析。结果：加替沙星组与左氧氟沙星组治疗泌尿系统感染的有效率分别为93.75%、87.50%(P0.05)；不良反应发生率分别为6.3%、8.3%(P0.05)；成本-效果比(C／E)分别为8.75、4.31。与左氧氟沙星组相比，加替沙星组每增加一个单位效果需多花费70.91元。结论：左氧氟沙星治疗泌尿系统感染的成本-效果比优于加替沙星。 [关键词] 加替沙星；左氧氟沙星；泌尿系统感染；成本-效果分析 [中图分类号]R956[文献标识码]A [文章编号]1673-7210（2007）08（a）-029-02 Pharmacoeconomic analysis of gatifloxacin and levofloxacin in the treatment of urinary system infection LIANG Yan-fang，KONG Ling-rui，DENG Xue-mei (The First People’s Hospital of Zhaoqing, Zhaoqing 526021,China) [Abstract] 0bjective: To compare the cost-effectiveness ratio of gatifloxacin and levofloxacin in the treatment of patients with infection in urinary system. Methods: Principle of pharmacoeconomics was adopted to analyze the cost-effectiveness of two treatment schemes. Results: The effective rates of gatifloxacin group and levofloxacin group in the treatment of urinary system infection were 93.75% and 87.50% (P0.05) respectively；the incidence rates of adverse reactions were 6.3% and 8.3%(P0.05)；The cost-effectiveness ratios (C/E) were 8.75 and 4.31 respectively. The cost for every one unit increment of effectiveness for gatifloxacin group was 70.91 Yuan more than that of the levofloxacin group. Conclusion: The cost-effectiveness ratio of levofloxacin is superior to that of gatifloxacin in the treatment of urinary system infection． [Key words] Gatifloxacin; Levofloxacin; Urinary system infection; Cost-effectiveness analysis 加替沙星与左氧氟沙星都是新一代高效广谱的喹诺酮类抗菌药物，临床上常用于治疗泌尿系统感染。为了使患者以最小的费用支出得到最佳的治疗方案，在选择药物不仅要考虑到其有效性、安全性，同时也要考虑其经济性。本研究应用药物经济学分析方法，对加替沙星与左氧氟沙星治疗泌尿系统感染的成本-效果进行比较分析，旨在为临床选择更加安全、有效、经济的抗菌药物。 1 资料与方法 1.1 临床资料 选择临床症状、体征及细菌学检查确诊为泌尿系统感染的门诊患者，排除对喹诺酮类药物过敏者、严重心肝肾造血系统损害者、孕妇和哺乳期妇女、有癫痫或精神病病史者等。 共入选病例96例，年龄为18～56岁，随机分成两组：A组（加替沙星组）48例，其中男26例，女22例，平均年龄39岁；B组（左氧氟沙星组）48例，其中男29例，女19例，平均年龄37岁。两组患者在性别、年龄、细菌感染情况、病情及病程等方面均无显著性差异，具有可比性（P0.05）。 1.2 方法 1.2.1给药方法A组：加替沙星注射液(利欧，浙江尖峰药业有限公司，0.1 g/2 ml)，静脉滴注，0.4