NMR有机氟谱的.ppt

19F 核磁共振;（一）19F NMR 的特点 （二）19F NMR 的基本规律 （三）含氟脂肪族化合物 19F NMR （四）含氟芳香族化合物 19F NMR （五）实例分析;（一）19F NMR 的特点 ① 19F 核特性 核 自旋量子数 相对灵敏度 天然丰度 V(MHz) 1H 1/2 100 99.98 60.O 13C 1/2 1.59 1.11 15.1 19F 1/2 83.3 100 56.4;② 化学位移区间大（一般300ppm）;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;③ 操作方便，任何不含氟的溶剂都可以使用， 便于反应跟踪;（二）19F NMR 的基本规律;化学位移 ① 标准：一般用CFCl3(F11)为标准，高场为负 ? CFCl3 = ? CF3CO2H - 77 ppm = ? PhCF3 - 63 ppm = ? C6F6 - 163 ppm = ? F2 + 430 ppm;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;③ 影响?值的因素 ? 电负性：与C、F连接的基团电负性增大，?移向低场 ?：CF3 ? CF2 ? CF NF3 CF4 BF3 ClF3 PF3 SiF4 ?： 142 -64 -129 83 -37 -172 电负性：3.0 2.5 2.0 3.0 2.1 1.8 ; 位阻效应：位阻增大，?向低场移动 CF4 CF3Cl CF2Cl2 CFCl3 -64 -40 -16 0 CF2I ＞ CF2Br ＞ CF2Cl ＞ CF3;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile 5.2.0.0. Copyright 2004-2011 Aspose Pty Ltd.;溶剂效应 F---SF4---N==SF2 DMSO 76.2 84.5 46.7 DMF 75.8 84.2 47.5 MeCN 73.1 84.0 49.5 Neat 70.3 83.7 52.7 C6H6 71.7 83.9 52.8 F113 70.0 83.6 53.3