自体角膜缘上皮干细胞移植及单纯翼状胬肉切除术疗效比较.docVIP

自体角膜缘上皮干细胞移植及单纯翼状胬肉切除术疗效比较[摘要] 目的：观察翼状胬肉单纯切除术与翼状胬肉切除加自体角膜缘干细胞移植术的临床疗效。方法：将2006年3月～2010年6月78例（93眼）翼状胬肉患者随机分为翼状胬肉单纯切除术组（对照组）及翼状胬肉切除加自体角膜缘干细胞移植术组（治疗组），比较其疗效。结果：采用翼状胬肉单纯切除术后患者复发率为13.3%，上皮修复时间为（5.83±0.84） d；而采用自体角膜缘干细胞移植后复发率仅为2.08%，上皮修复时间为（3.02±0.79） d，且两者相比，差异有统计学意义（P＜0.05）。结论：翼状胬肉切除加自体角膜缘干细胞移植术与翼状胬肉单纯切除术相比，可以有效地降低复发率，而且缩短角膜上皮修复时间，是治疗翼状胬肉较为理想有效的方法。 [关键词] 自体角膜缘上皮干细胞；翼状胬肉；疗效；切除术 [中图分类号] R777.33 [文献标识码]C[文章编号]1674-4721（2011）07（b）-174-02 Comparison of efficacy between limbal epithelial stem cell autografting transplantation and simple pterygium excision LI Xiaojun The People’s Hospital of Yuanling County, Hunan Province, Yuanling 419600, China [Abstract] Objective: To analyze 78 cases (93 eyes) of pterygium by operative treatment in our hospital and to explore the curative effect of pterygium excision with limbal stem cell autograft transplantation for treatment of pterygium. Methods: 78 cases (93 eyes) were divided into two groups randomly． 36 patients (45 eyes) with primary pterygium were treated by simple excision technique patients; 42 patients (48 eyes) with primary pterygium were treated by limbal stem cells autografting technique． Results: Recurrent rate was 13.3％ and corneal epithelium were recovered with (5.83±0.84) days in simple pterygium excision group, but in the therapeutic group the recurrent rate was 2.08% and corneal epithelium were recovered with (3.02±0.79) days． There was statistically significant difference in the recurrence rate between the patients who underwent simple excision and those who underwent limbal conjunctival autografting(P＜0.05). Conclusion: Limbal stem cells autografting is an effective surgical technique for the treatment of primary pterygium．It has a low recurrence rate when compared with the simple excision technique． [Key words] Limbal epithelial stem cell autografting; Pterygium; Curative effect; Resection 翼状胬肉是眼科常见病，手术切除是治疗的主要手段，但翼状胬肉单纯切除手术的复发率高。随着角膜缘干细胞研究的不断深入，翼状胬肉切除加自体角膜缘上皮干细胞移植逐渐成为治疗翼状胬肉患者的主要手段。现将本院采用翼状胬肉