99mtc标记的亚锡植酸钠联合超声造影在早期乳腺癌腋窝前哨淋巴结.pdfVIP

第42 卷 第1期 兰州大学学报（医学版） Vol.42 No. 1 2016 年2 月 Journal of Lanzhou University （Medical Sciences ） Feb. 2016 文章编号：1000-2812 (2016) 01-0021-04 99mTc 标记的亚锡植酸钠联合超声造影在早期乳腺癌 腋窝前哨淋巴结活检术中的应用 包蔚郁，白晓蓉，郭雁翔，高 晨，杨碎胜 甘肃省肿瘤医院 乳腺科，甘肃 兰州 730050 99m 摘要：目的目的 探讨 Tc 标记的亚锡植酸钠对乳腺癌腋窝淋巴结的示踪效果及其安全性。方法方法 60 例临床诊断的 99m cT N - M 期乳腺癌患者在术前采用 Tc 标记的亚锡植酸钠进行淋巴结示踪。术前乳晕皮下注射亚甲蓝注射液2 mL ， is-3 0 1 0 术中观察γ射线探测仪计数及蓝染情况，并将前哨淋巴结及非前哨淋巴结送术中细胞学、术中冰冻、术后病理检查。 结果结果 60 例患者淋巴结检出率为100% ，分别检出淋巴结12 ~27 枚，平均每例检出16.4 枚，共1 006 枚；蓝染淋巴结共 646 枚，蓝染率为64.2% 。前哨淋巴结检出灵敏度86.7% ，准确率98.4% ，假阴性率6.7% 。所有患者经14 ~24 个月的随 99m 访，均未出现复发转移。结论结论 利用 Tc 标记的亚锡植酸钠行腋窝前哨淋巴结活检术配合术前超声造影定位、定性，可 达到良好的前哨淋巴结示踪效果及术前筛查，有效避免转移淋巴结的漏检，提高前哨淋巴结活检术的检出率、准确 率，降低假阴性率。 关键词：早期乳腺癌；前哨淋巴结；活检；亚锡植酸钠；超声造影 中图分类号：R737.9 ，R730.4 文献标识码：A doi ：10.13885/j.issn. 1000-2812.2016.01.004 Application of 99mTc labeled sodium phytate and stannous chloride combined with contrast-enhanced ultrasonography in axillary sentinel lymph node biopsy of early breast cancer Bao Wei-yu, Bai Xiao-rong, Guo Yang-xiang, Gao Chen, Yang Sui-sheng Department of Breast Surgery, Tumor Hospital of Gansu Province, Lanzhou 730050, China Abstract ：：Objective To explore the tracing effect and the safety of 99mTc labeled sodium phytate and stannous chloride on axillary lymph node of early breast cancer. Methods 60 patients with clinically diagnosed early breast cancer (cTis- 3N0- 1M0) were performed lymph nodes tracing by 99mTc labeled sodium phytate and stannous chloride injection. The areola subcutaneous injection of 2 mL methylthioninium chloride was per- formed preoperatively. Gamma ray detector counting and blue staining of axillary lymph node were observed intraoperatively, sentinel lymph node and non sentinel lymph node were examined